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Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralization by Anti-V1V2 Monoclonal Antibodies

HIV-1 envelope glycoproteins (Env) are the only viral antigens present on the virus surface and serve as the key targets for virus-neutralizing antibodies. However, HIV-1 deploys multiple strategies to shield the vulnerable sites on its Env from neutralizing antibodies. The V1V2 domain located at th...

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Detalles Bibliográficos
Autores principales:	Shen, Guomiao, Upadhyay, Chitra, Zhang, Jing, Pan, Ruimin, Zolla-Pazner, Susan, Kong, Xiang-Peng, Hioe, Catarina E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619609/ https://www.ncbi.nlm.nih.gov/pubmed/26491873 http://dx.doi.org/10.1371/journal.pone.0141233

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