Cargando…
The Potential for a Blood Test for Scabies
BACKGROUND: Scabies afflicts millions of people worldwide, but it is very difficult to diagnose by the usual skin scrape test, and a presumptive diagnosis is often made based on clinical signs such as rash and intense itch. A sensitive and specific blood test to detect scabies would allow a physicia...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619658/ https://www.ncbi.nlm.nih.gov/pubmed/26492406 http://dx.doi.org/10.1371/journal.pntd.0004188 |
_version_ | 1782397153187987456 |
---|---|
author | Arlian, Larry G. Feldmeier, Hermann Morgan, Marjorie S. |
author_facet | Arlian, Larry G. Feldmeier, Hermann Morgan, Marjorie S. |
author_sort | Arlian, Larry G. |
collection | PubMed |
description | BACKGROUND: Scabies afflicts millions of people worldwide, but it is very difficult to diagnose by the usual skin scrape test, and a presumptive diagnosis is often made based on clinical signs such as rash and intense itch. A sensitive and specific blood test to detect scabies would allow a physician to quickly make a correct diagnosis. OBJECTIVE: Our objective was to profile the mite-specific antibodies present in the sera of patients with ordinary scabies. METHODS: Sera of 91 patients were screened for Ig, IgD, IgE, IgG and IgM antibodies to S. scabiei, as well as to the house dust mites Dermatophagoides farinae, D. pteronyssinus and Euroglyphus maynei. RESULTS: 45%, 27% and 2.2% of the patients had measurable amounts of mixed Ig, IgG and IgE that recognized scabies mite antigens. However, 73.6% of the scabies patients had serum IgM that recognized scabies proteins, and all except two of them also had IgM that recognized all of the three species of dust mites. No patient had serum antibody exclusively reactive to scabies mite antigens. CONCLUSIONS: Co-sensitization or cross-reactivity between antigens from scabies and house dust mites confounds developing a blood test for scabies. |
format | Online Article Text |
id | pubmed-4619658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46196582015-10-29 The Potential for a Blood Test for Scabies Arlian, Larry G. Feldmeier, Hermann Morgan, Marjorie S. PLoS Negl Trop Dis Research Article BACKGROUND: Scabies afflicts millions of people worldwide, but it is very difficult to diagnose by the usual skin scrape test, and a presumptive diagnosis is often made based on clinical signs such as rash and intense itch. A sensitive and specific blood test to detect scabies would allow a physician to quickly make a correct diagnosis. OBJECTIVE: Our objective was to profile the mite-specific antibodies present in the sera of patients with ordinary scabies. METHODS: Sera of 91 patients were screened for Ig, IgD, IgE, IgG and IgM antibodies to S. scabiei, as well as to the house dust mites Dermatophagoides farinae, D. pteronyssinus and Euroglyphus maynei. RESULTS: 45%, 27% and 2.2% of the patients had measurable amounts of mixed Ig, IgG and IgE that recognized scabies mite antigens. However, 73.6% of the scabies patients had serum IgM that recognized scabies proteins, and all except two of them also had IgM that recognized all of the three species of dust mites. No patient had serum antibody exclusively reactive to scabies mite antigens. CONCLUSIONS: Co-sensitization or cross-reactivity between antigens from scabies and house dust mites confounds developing a blood test for scabies. Public Library of Science 2015-10-22 /pmc/articles/PMC4619658/ /pubmed/26492406 http://dx.doi.org/10.1371/journal.pntd.0004188 Text en © 2015 Arlian et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Arlian, Larry G. Feldmeier, Hermann Morgan, Marjorie S. The Potential for a Blood Test for Scabies |
title | The Potential for a Blood Test for Scabies |
title_full | The Potential for a Blood Test for Scabies |
title_fullStr | The Potential for a Blood Test for Scabies |
title_full_unstemmed | The Potential for a Blood Test for Scabies |
title_short | The Potential for a Blood Test for Scabies |
title_sort | potential for a blood test for scabies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619658/ https://www.ncbi.nlm.nih.gov/pubmed/26492406 http://dx.doi.org/10.1371/journal.pntd.0004188 |
work_keys_str_mv | AT arlianlarryg thepotentialforabloodtestforscabies AT feldmeierhermann thepotentialforabloodtestforscabies AT morganmarjories thepotentialforabloodtestforscabies AT arlianlarryg potentialforabloodtestforscabies AT feldmeierhermann potentialforabloodtestforscabies AT morganmarjories potentialforabloodtestforscabies |