Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells

Recent efforts to cure human immunodeficiency virus type-1 (HIV-1) infection have focused on developing latency reversing agents as a first step to eradicate the latent reservoir. The histone deacetylase inhibitor, vorinostat, has been shown to activate HIV RNA transcription in CD4+ T-cells and alte...

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Detalles Bibliográficos
Autores principales: Ke, Ruian, Lewin, Sharon R., Elliott, Julian H, Perelson, Alan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619772/
https://www.ncbi.nlm.nih.gov/pubmed/26496627
http://dx.doi.org/10.1371/journal.ppat.1005237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619772/
https://www.ncbi.nlm.nih.gov/pubmed/26496627
http://dx.doi.org/10.1371/journal.ppat.1005237

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