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Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype

Ischemic preconditioning (IP) of the liver by a brief interruption of the blood flow protects the damage induced by a subsequent ischemia/reperfusion (I/R) preventing parenchymal and nonparenchymal liver cell damage. The discovery of IP has shown the existence of intrinsic systems of cytoprotection...

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Autores principales: Alchera, Elisa, Imarisio, Chiara, Mandili, Giorgia, Merlin, Simone, Chandrashekar, Bangalore R., Novelli, Francesco, Follenzi, Antonia, Carini, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619783/
https://www.ncbi.nlm.nih.gov/pubmed/26539478
http://dx.doi.org/10.1155/2015/286746
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author Alchera, Elisa
Imarisio, Chiara
Mandili, Giorgia
Merlin, Simone
Chandrashekar, Bangalore R.
Novelli, Francesco
Follenzi, Antonia
Carini, Rita
author_facet Alchera, Elisa
Imarisio, Chiara
Mandili, Giorgia
Merlin, Simone
Chandrashekar, Bangalore R.
Novelli, Francesco
Follenzi, Antonia
Carini, Rita
author_sort Alchera, Elisa
collection PubMed
description Ischemic preconditioning (IP) of the liver by a brief interruption of the blood flow protects the damage induced by a subsequent ischemia/reperfusion (I/R) preventing parenchymal and nonparenchymal liver cell damage. The discovery of IP has shown the existence of intrinsic systems of cytoprotection whose activation can stave off the progression of irreversible tissue damage. Deciphering the molecular mediators that underlie the cytoprotective effects of preconditioning can pave the way to important therapeutic possibilities. Pharmacological activation of critical mediators of IP would be expected to emulate or even to intensify its salubrious effects. In vitro and in vivo studies have demonstrated the role of the adenosine A2a receptor (A2aR) as a trigger of liver IP. This review will provide insight into the phenotypic changes that underline the resistance to death of liver cells preconditioned by pharmacological activation of A2aR and their implications to develop innovative strategies against liver IR damage.
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spelling pubmed-46197832015-11-04 Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype Alchera, Elisa Imarisio, Chiara Mandili, Giorgia Merlin, Simone Chandrashekar, Bangalore R. Novelli, Francesco Follenzi, Antonia Carini, Rita Biomed Res Int Review Article Ischemic preconditioning (IP) of the liver by a brief interruption of the blood flow protects the damage induced by a subsequent ischemia/reperfusion (I/R) preventing parenchymal and nonparenchymal liver cell damage. The discovery of IP has shown the existence of intrinsic systems of cytoprotection whose activation can stave off the progression of irreversible tissue damage. Deciphering the molecular mediators that underlie the cytoprotective effects of preconditioning can pave the way to important therapeutic possibilities. Pharmacological activation of critical mediators of IP would be expected to emulate or even to intensify its salubrious effects. In vitro and in vivo studies have demonstrated the role of the adenosine A2a receptor (A2aR) as a trigger of liver IP. This review will provide insight into the phenotypic changes that underline the resistance to death of liver cells preconditioned by pharmacological activation of A2aR and their implications to develop innovative strategies against liver IR damage. Hindawi Publishing Corporation 2015 2015-10-11 /pmc/articles/PMC4619783/ /pubmed/26539478 http://dx.doi.org/10.1155/2015/286746 Text en Copyright © 2015 Elisa Alchera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Alchera, Elisa
Imarisio, Chiara
Mandili, Giorgia
Merlin, Simone
Chandrashekar, Bangalore R.
Novelli, Francesco
Follenzi, Antonia
Carini, Rita
Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
title Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
title_full Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
title_fullStr Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
title_full_unstemmed Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
title_short Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
title_sort pharmacological preconditioning by adenosine a2a receptor stimulation: features of the protected liver cell phenotype
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619783/
https://www.ncbi.nlm.nih.gov/pubmed/26539478
http://dx.doi.org/10.1155/2015/286746
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