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A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography

OBJECTIVE: To compare the effect of oral glucose given with or without facilitated tucking (FT), versus placebo (water) to facilitate image acquisition during a targeted neonatal echocardiography (TNE). DESIGN: Factorial, double blind, randomized controlled trial. SETTING: Tertiary neonatal intensiv...

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Autores principales: Lavoie, Pascal M., Stritzke, Amelie, Ting, Joseph, Jabr, Mohammad, Jain, Amish, Kwan, Eddie, Chakkarapani, Ela, Brooks, Paul, Brant, Rollin, McNamara, Patrick J., Holsti, Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619855/
https://www.ncbi.nlm.nih.gov/pubmed/26496361
http://dx.doi.org/10.1371/journal.pone.0141015
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author Lavoie, Pascal M.
Stritzke, Amelie
Ting, Joseph
Jabr, Mohammad
Jain, Amish
Kwan, Eddie
Chakkarapani, Ela
Brooks, Paul
Brant, Rollin
McNamara, Patrick J.
Holsti, Liisa
author_facet Lavoie, Pascal M.
Stritzke, Amelie
Ting, Joseph
Jabr, Mohammad
Jain, Amish
Kwan, Eddie
Chakkarapani, Ela
Brooks, Paul
Brant, Rollin
McNamara, Patrick J.
Holsti, Liisa
author_sort Lavoie, Pascal M.
collection PubMed
description OBJECTIVE: To compare the effect of oral glucose given with or without facilitated tucking (FT), versus placebo (water) to facilitate image acquisition during a targeted neonatal echocardiography (TNE). DESIGN: Factorial, double blind, randomized controlled trial. SETTING: Tertiary neonatal intensive care unit (NICU). PATIENTS: Infants born between 26 and 42 weeks of gestation (GA). INTERVENTIONS: One of four treatment groups: oral water (placebo), oral glucose (25%), facilitated tucking with oral water or facilitated tucking with oral glucose, during a single, structured TNE. All infants received a soother. MAIN OUTCOME MEASURE: Change in Behavioral Indicators of Infant Pain (BIIP) scores. RESULTS: 104 preterm infants were randomized (mean ± SD GA: 33.4 ± 3.5 weeks). BIIP scores remained low during the echocardiography scan (median, [IQ range]: 0, [0 to 1]). There were no differences in the level of agitation of infants amongst the treatment groups, with estimated reductions in mean BIIP relative to control of 0.27 (95%CI -0.40 to 0.94) with use of oral glucose and .04 (-0.63 to 0.70) with facilitated tucking. There were also no differences between treatment groups in the quality and duration of the echocardiography scans. CONCLUSIONS: In stable infants in the NICU, a TNE can be performed with minimal disruption in a majority of cases, simply by providing a soother. The use of 25% glucose water in this context did not provide further benefit in reducing agitation and improving image acquisition. CLINICAL TRIAL REGISTRATION: Clinical Trials.gov: NCT01253889
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spelling pubmed-46198552015-10-29 A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography Lavoie, Pascal M. Stritzke, Amelie Ting, Joseph Jabr, Mohammad Jain, Amish Kwan, Eddie Chakkarapani, Ela Brooks, Paul Brant, Rollin McNamara, Patrick J. Holsti, Liisa PLoS One Research Article OBJECTIVE: To compare the effect of oral glucose given with or without facilitated tucking (FT), versus placebo (water) to facilitate image acquisition during a targeted neonatal echocardiography (TNE). DESIGN: Factorial, double blind, randomized controlled trial. SETTING: Tertiary neonatal intensive care unit (NICU). PATIENTS: Infants born between 26 and 42 weeks of gestation (GA). INTERVENTIONS: One of four treatment groups: oral water (placebo), oral glucose (25%), facilitated tucking with oral water or facilitated tucking with oral glucose, during a single, structured TNE. All infants received a soother. MAIN OUTCOME MEASURE: Change in Behavioral Indicators of Infant Pain (BIIP) scores. RESULTS: 104 preterm infants were randomized (mean ± SD GA: 33.4 ± 3.5 weeks). BIIP scores remained low during the echocardiography scan (median, [IQ range]: 0, [0 to 1]). There were no differences in the level of agitation of infants amongst the treatment groups, with estimated reductions in mean BIIP relative to control of 0.27 (95%CI -0.40 to 0.94) with use of oral glucose and .04 (-0.63 to 0.70) with facilitated tucking. There were also no differences between treatment groups in the quality and duration of the echocardiography scans. CONCLUSIONS: In stable infants in the NICU, a TNE can be performed with minimal disruption in a majority of cases, simply by providing a soother. The use of 25% glucose water in this context did not provide further benefit in reducing agitation and improving image acquisition. CLINICAL TRIAL REGISTRATION: Clinical Trials.gov: NCT01253889 Public Library of Science 2015-10-23 /pmc/articles/PMC4619855/ /pubmed/26496361 http://dx.doi.org/10.1371/journal.pone.0141015 Text en © 2015 Lavoie et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lavoie, Pascal M.
Stritzke, Amelie
Ting, Joseph
Jabr, Mohammad
Jain, Amish
Kwan, Eddie
Chakkarapani, Ela
Brooks, Paul
Brant, Rollin
McNamara, Patrick J.
Holsti, Liisa
A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
title A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
title_full A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
title_fullStr A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
title_full_unstemmed A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
title_short A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
title_sort randomized controlled trial of the use of oral glucose with or without gentle facilitated tucking of infants during neonatal echocardiography
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619855/
https://www.ncbi.nlm.nih.gov/pubmed/26496361
http://dx.doi.org/10.1371/journal.pone.0141015
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