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Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease

Behçet's disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gam...

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Detalles Bibliográficos
Autores principales: Hasan, Md. Samiul, Bergmeier, Lesley Ann, Petrushkin, Harry, Fortune, Farida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619955/
https://www.ncbi.nlm.nih.gov/pubmed/26539557
http://dx.doi.org/10.1155/2015/705831
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author Hasan, Md. Samiul
Bergmeier, Lesley Ann
Petrushkin, Harry
Fortune, Farida
author_facet Hasan, Md. Samiul
Bergmeier, Lesley Ann
Petrushkin, Harry
Fortune, Farida
author_sort Hasan, Md. Samiul
collection PubMed
description Behçet's disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role. γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of γδ T cells in BD. We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis.
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spelling pubmed-46199552015-11-04 Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease Hasan, Md. Samiul Bergmeier, Lesley Ann Petrushkin, Harry Fortune, Farida J Immunol Res Review Article Behçet's disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role. γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of γδ T cells in BD. We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis. Hindawi Publishing Corporation 2015 2015-10-11 /pmc/articles/PMC4619955/ /pubmed/26539557 http://dx.doi.org/10.1155/2015/705831 Text en Copyright © 2015 Md. Samiul Hasan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hasan, Md. Samiul
Bergmeier, Lesley Ann
Petrushkin, Harry
Fortune, Farida
Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease
title Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease
title_full Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease
title_fullStr Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease
title_full_unstemmed Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease
title_short Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease
title_sort gamma delta (γδ) t cells and their involvement in behçet's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619955/
https://www.ncbi.nlm.nih.gov/pubmed/26539557
http://dx.doi.org/10.1155/2015/705831
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