Cargando…

Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men

The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, includi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Sun Min, Cho, Young Hye, Lee, Sang Yeoup, Jeong, Dong Wook, Cho, A Ra, Jeon, Jeong Suk, Park, Eun-Ju, Kim, Yun Jin, Lee, Jeong Gyu, Yi, Yu Hyeon, Tak, Young Jin, Hwang, Hye Rim, Lee, Seung-Hun, Han, Junehee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619966/
https://www.ncbi.nlm.nih.gov/pubmed/26538829
http://dx.doi.org/10.1155/2015/524291
_version_ 1782397223530659840
author Lee, Sun Min
Cho, Young Hye
Lee, Sang Yeoup
Jeong, Dong Wook
Cho, A Ra
Jeon, Jeong Suk
Park, Eun-Ju
Kim, Yun Jin
Lee, Jeong Gyu
Yi, Yu Hyeon
Tak, Young Jin
Hwang, Hye Rim
Lee, Seung-Hun
Han, Junehee
author_facet Lee, Sun Min
Cho, Young Hye
Lee, Sang Yeoup
Jeong, Dong Wook
Cho, A Ra
Jeon, Jeong Suk
Park, Eun-Ju
Kim, Yun Jin
Lee, Jeong Gyu
Yi, Yu Hyeon
Tak, Young Jin
Hwang, Hye Rim
Lee, Seung-Hun
Han, Junehee
author_sort Lee, Sun Min
collection PubMed
description The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC.
format Online
Article
Text
id pubmed-4619966
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-46199662015-11-04 Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men Lee, Sun Min Cho, Young Hye Lee, Sang Yeoup Jeong, Dong Wook Cho, A Ra Jeon, Jeong Suk Park, Eun-Ju Kim, Yun Jin Lee, Jeong Gyu Yi, Yu Hyeon Tak, Young Jin Hwang, Hye Rim Lee, Seung-Hun Han, Junehee Mediators Inflamm Research Article The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC. Hindawi Publishing Corporation 2015 2015-10-11 /pmc/articles/PMC4619966/ /pubmed/26538829 http://dx.doi.org/10.1155/2015/524291 Text en Copyright © 2015 Sun Min Lee et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lee, Sun Min
Cho, Young Hye
Lee, Sang Yeoup
Jeong, Dong Wook
Cho, A Ra
Jeon, Jeong Suk
Park, Eun-Ju
Kim, Yun Jin
Lee, Jeong Gyu
Yi, Yu Hyeon
Tak, Young Jin
Hwang, Hye Rim
Lee, Seung-Hun
Han, Junehee
Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men
title Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men
title_full Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men
title_fullStr Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men
title_full_unstemmed Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men
title_short Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men
title_sort urinary malondialdehyde is associated with visceral abdominal obesity in middle-aged men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619966/
https://www.ncbi.nlm.nih.gov/pubmed/26538829
http://dx.doi.org/10.1155/2015/524291
work_keys_str_mv AT leesunmin urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT choyounghye urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT leesangyeoup urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT jeongdongwook urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT choara urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT jeonjeongsuk urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT parkeunju urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT kimyunjin urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT leejeonggyu urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT yiyuhyeon urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT takyoungjin urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT hwanghyerim urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT leeseunghun urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen
AT hanjunehee urinarymalondialdehydeisassociatedwithvisceralabdominalobesityinmiddleagedmen