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Is There a Role for Base Excision Repair in Estrogen/Estrogen Receptor-Driven Breast Cancers?

Estrogen and estrogen metabolite-induced reactive oxygen species generation can promote oxidative DNA base damage. If unrepaired, base damaging lesions could accelerate mutagenesis, leading to a “mutator phenotype” characterized by aggressive behavior in estrogen-estrogen receptor (ER)-driven breast...

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Detalles Bibliográficos
Autores principales:	Abdel-Fatah, Tarek M.A., Perry, Christina, Arora, Arvind, Thompson, Nicola, Doherty, Rachel, Moseley, Paul M., Green, Andrew R., Chan, Stephen Y.T., Ellis, Ian O., Madhusudan, Srinivasan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2014
Materias:	News & Views
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620128/ https://www.ncbi.nlm.nih.gov/pubmed/25111287 http://dx.doi.org/10.1089/ars.2014.6077

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