Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder

OBJECTIVE: We tested for association of the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. METHODS: A total of 181 subjects with ADHD along with both of their biological parents were...

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Detalles Bibliográficos
Autores principales: Park, Subin, Park, Jong-Eun, Yoo, Hee Jeong, Kim, Jae-Won, Cheong, Jae Hoon, Han, Doug Hyun, Kim, Yeni, Kim, Bung-Nyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620316/
https://www.ncbi.nlm.nih.gov/pubmed/26508970
http://dx.doi.org/10.4306/pi.2015.12.4.563
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author Park, Subin
Park, Jong-Eun
Yoo, Hee Jeong
Kim, Jae-Won
Cheong, Jae Hoon
Han, Doug Hyun
Kim, Yeni
Kim, Bung-Nyun
author_facet Park, Subin
Park, Jong-Eun
Yoo, Hee Jeong
Kim, Jae-Won
Cheong, Jae Hoon
Han, Doug Hyun
Kim, Yeni
Kim, Bung-Nyun
author_sort Park, Subin
collection PubMed
description OBJECTIVE: We tested for association of the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. METHODS: A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. RESULTS: In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ(2)=4.21, p=0.040). CONCLUSION: These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
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spelling pubmed-46203162015-10-27 Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder Park, Subin Park, Jong-Eun Yoo, Hee Jeong Kim, Jae-Won Cheong, Jae Hoon Han, Doug Hyun Kim, Yeni Kim, Bung-Nyun Psychiatry Investig Brief Report OBJECTIVE: We tested for association of the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. METHODS: A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. RESULTS: In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ(2)=4.21, p=0.040). CONCLUSION: These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations. Korean Neuropsychiatric Association 2015-10 2015-09-30 /pmc/articles/PMC4620316/ /pubmed/26508970 http://dx.doi.org/10.4306/pi.2015.12.4.563 Text en Copyright © 2015 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Park, Subin
Park, Jong-Eun
Yoo, Hee Jeong
Kim, Jae-Won
Cheong, Jae Hoon
Han, Doug Hyun
Kim, Yeni
Kim, Bung-Nyun
Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
title Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
title_full Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
title_fullStr Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
title_full_unstemmed Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
title_short Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
title_sort association of the catechol o-methyltransferase val158-met polymorphism and reduced interference control in korean children with attention-deficit hyperactivity disorder
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620316/
https://www.ncbi.nlm.nih.gov/pubmed/26508970
http://dx.doi.org/10.4306/pi.2015.12.4.563
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