Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia

Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids....

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Detalles Bibliográficos
Autores principales: Oh, Ji Hyun, Oh, Dong Jun, Koo, So-My, Kim, Yang Ki, Kim, Ki Up, Kim, Hyun Jo, Kim, Dong Won, Uh, Soo-Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620339/
https://www.ncbi.nlm.nih.gov/pubmed/26508933
http://dx.doi.org/10.4046/trd.2015.78.4.401
Descripción
Sumario:Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids. A few reports showed treatment failure with macrolides in patients with COP who were resistant to steroids. In this report, we described two cases of COP who showed different responses to clarithromycin. One recovered completely, but the other gradually showed lung fibrosis with clarithromycin.

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