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Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles
Contrast-enhanced MRI lymphography shows potential to identify alterations in lymph drainage through lymph nodes (LNs) in cancer and other diseases. MRI studies have typically used low molecular weight gadolinium contrast agents, however larger gadolinium-loaded nanoparticles possess characteristics...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620490/ https://www.ncbi.nlm.nih.gov/pubmed/26497382 http://dx.doi.org/10.1038/srep15641 |
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author | Partridge, S. C. Kurland, B. F. Liu, C.-L. Ho, R. J. Y. Ruddell, A. |
author_facet | Partridge, S. C. Kurland, B. F. Liu, C.-L. Ho, R. J. Y. Ruddell, A. |
author_sort | Partridge, S. C. |
collection | PubMed |
description | Contrast-enhanced MRI lymphography shows potential to identify alterations in lymph drainage through lymph nodes (LNs) in cancer and other diseases. MRI studies have typically used low molecular weight gadolinium contrast agents, however larger gadolinium-loaded nanoparticles possess characteristics that could improve the specificity and sensitivity of lymphography. The performance of three gadolinium contrast agents with different sizes and properties was compared by 3T MRI after subcutaneous injection. Mice bearing B16-F10 melanoma footpad tumors were imaged to assess tumor-induced alterations in lymph drainage through tumor-draining popliteal and inguinal LNs versus contralateral uninvolved drainage. Gadolinium lipid nanoparticles were able to identify tumor-induced alterations in contrast agent drainage into the popliteal LN, while lower molecular weight or albumin-binding gadolinium agents were less effective. All of the contrast agents distributed in foci around the cortex and medulla of tumor-draining popliteal LNs, while they were restricted to the cortex of non-draining LNs. Surprisingly, second-tier tumor-draining inguinal LNs exhibited reduced uptake, indicating that tumors can also divert LN drainage. These characteristics of tumor-induced lymph drainage could be useful for diagnosis of LN pathology in cancer and other diseases. The preferential uptake of nanoparticle contrasts into tumor-draining LNs could also allow selective targeting of therapies to tumor-draining LNs. |
format | Online Article Text |
id | pubmed-4620490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46204902015-10-29 Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles Partridge, S. C. Kurland, B. F. Liu, C.-L. Ho, R. J. Y. Ruddell, A. Sci Rep Article Contrast-enhanced MRI lymphography shows potential to identify alterations in lymph drainage through lymph nodes (LNs) in cancer and other diseases. MRI studies have typically used low molecular weight gadolinium contrast agents, however larger gadolinium-loaded nanoparticles possess characteristics that could improve the specificity and sensitivity of lymphography. The performance of three gadolinium contrast agents with different sizes and properties was compared by 3T MRI after subcutaneous injection. Mice bearing B16-F10 melanoma footpad tumors were imaged to assess tumor-induced alterations in lymph drainage through tumor-draining popliteal and inguinal LNs versus contralateral uninvolved drainage. Gadolinium lipid nanoparticles were able to identify tumor-induced alterations in contrast agent drainage into the popliteal LN, while lower molecular weight or albumin-binding gadolinium agents were less effective. All of the contrast agents distributed in foci around the cortex and medulla of tumor-draining popliteal LNs, while they were restricted to the cortex of non-draining LNs. Surprisingly, second-tier tumor-draining inguinal LNs exhibited reduced uptake, indicating that tumors can also divert LN drainage. These characteristics of tumor-induced lymph drainage could be useful for diagnosis of LN pathology in cancer and other diseases. The preferential uptake of nanoparticle contrasts into tumor-draining LNs could also allow selective targeting of therapies to tumor-draining LNs. Nature Publishing Group 2015-10-26 /pmc/articles/PMC4620490/ /pubmed/26497382 http://dx.doi.org/10.1038/srep15641 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Partridge, S. C. Kurland, B. F. Liu, C.-L. Ho, R. J. Y. Ruddell, A. Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles |
title | Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles |
title_full | Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles |
title_fullStr | Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles |
title_full_unstemmed | Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles |
title_short | Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles |
title_sort | tumor-induced lymph node alterations detected by mri lymphography using gadolinium nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620490/ https://www.ncbi.nlm.nih.gov/pubmed/26497382 http://dx.doi.org/10.1038/srep15641 |
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