Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapit...

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Detalles Bibliográficos
Autores principales: Freedman, Benjamin S., Brooks, Craig R., Lam, Albert Q., Fu, Hongxia, Morizane, Ryuji, Agrawal, Vishesh, Saad, Abdelaziz F., Li, Michelle K., Hughes, Michael R., Werff, Ryan Vander, Peters, Derek T., Lu, Junjie, Baccei, Anna, Siedlecki, Andrew M., Valerius, M. Todd, Musunuru, Kiran, McNagny, Kelly M., Steinman, Theodore I., Zhou, Jing, Lerou, Paul H., Bonventre, Joseph V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620584/
https://www.ncbi.nlm.nih.gov/pubmed/26493500
http://dx.doi.org/10.1038/ncomms9715

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