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Medical Therapy of Fibrostenotic Crohn's Disease

INTRODUCTION: The present review serves to provide a concise overview of the current knowledge on therapeutic strategies with regard to fibrostenotic lesions in Crohn's disease. METHODS: A literature search was performed focusing on the last 5 years, and current concepts of pathophysiology, epi...

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Autor principal: Siegmund, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620591/
https://www.ncbi.nlm.nih.gov/pubmed/26557834
http://dx.doi.org/10.1159/000435868
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author Siegmund, Britta
author_facet Siegmund, Britta
author_sort Siegmund, Britta
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description INTRODUCTION: The present review serves to provide a concise overview of the current knowledge on therapeutic strategies with regard to fibrostenotic lesions in Crohn's disease. METHODS: A literature search was performed focusing on the last 5 years, and current concepts of pathophysiology, epidemiology, and treatment have been summarized. RESULTS: Fibrostenotic lesions in Crohn's disease are currently considered to be a consequence of the chronic inflammatory nature of the disease. Hence, therapeutic strategies are limited to the concept that early treatment of the inflammatory lesions can prevent structural changes, and to various endoscopic and surgical approaches. Direct targeting of the fibrostenotic lesion itself has not been the focus until now. This review will provide an overview of the pathophysiology and epidemiology of fibrostenotic lesions including current therapeutic approaches. Since research with regard to other organ systems and fibrosis is far more advanced, current strategies from available studies in these areas will be discussed. The results and the potential impact for Crohn's disease will be considered. CONCLUSION: The vision of these approaches is to reverse structural changes and restore normal function.
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spelling pubmed-46205912016-08-01 Medical Therapy of Fibrostenotic Crohn's Disease Siegmund, Britta Viszeralmedizin Review Article INTRODUCTION: The present review serves to provide a concise overview of the current knowledge on therapeutic strategies with regard to fibrostenotic lesions in Crohn's disease. METHODS: A literature search was performed focusing on the last 5 years, and current concepts of pathophysiology, epidemiology, and treatment have been summarized. RESULTS: Fibrostenotic lesions in Crohn's disease are currently considered to be a consequence of the chronic inflammatory nature of the disease. Hence, therapeutic strategies are limited to the concept that early treatment of the inflammatory lesions can prevent structural changes, and to various endoscopic and surgical approaches. Direct targeting of the fibrostenotic lesion itself has not been the focus until now. This review will provide an overview of the pathophysiology and epidemiology of fibrostenotic lesions including current therapeutic approaches. Since research with regard to other organ systems and fibrosis is far more advanced, current strategies from available studies in these areas will be discussed. The results and the potential impact for Crohn's disease will be considered. CONCLUSION: The vision of these approaches is to reverse structural changes and restore normal function. S. Karger AG 2015-08 2015-07-28 /pmc/articles/PMC4620591/ /pubmed/26557834 http://dx.doi.org/10.1159/000435868 Text en Copyright © 2015 by S. Karger AG, Basel
spellingShingle Review Article
Siegmund, Britta
Medical Therapy of Fibrostenotic Crohn's Disease
title Medical Therapy of Fibrostenotic Crohn's Disease
title_full Medical Therapy of Fibrostenotic Crohn's Disease
title_fullStr Medical Therapy of Fibrostenotic Crohn's Disease
title_full_unstemmed Medical Therapy of Fibrostenotic Crohn's Disease
title_short Medical Therapy of Fibrostenotic Crohn's Disease
title_sort medical therapy of fibrostenotic crohn's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620591/
https://www.ncbi.nlm.nih.gov/pubmed/26557834
http://dx.doi.org/10.1159/000435868
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