Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration

Denosumab is a human monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women with a high risk of fractures. To our knowledge, no cases of desensitization to this drug have been described in the literature. We report the first case of generalized urticarial reaction an...

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Autores principales: Gutiérrez-Fernández, D., Cruz, María-Jesús, Foncubierta-Fernández, A., Moreno-Ancillo, A., Fernández-Anguita, M. J., Medina-Varo, F., Andres-García, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620716/
https://www.ncbi.nlm.nih.gov/pubmed/26504466
http://dx.doi.org/10.1186/s13223-015-0097-6
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author Gutiérrez-Fernández, D.
Cruz, María-Jesús
Foncubierta-Fernández, A.
Moreno-Ancillo, A.
Fernández-Anguita, M. J.
Medina-Varo, F.
Andres-García, J. A.
author_facet Gutiérrez-Fernández, D.
Cruz, María-Jesús
Foncubierta-Fernández, A.
Moreno-Ancillo, A.
Fernández-Anguita, M. J.
Medina-Varo, F.
Andres-García, J. A.
author_sort Gutiérrez-Fernández, D.
collection PubMed
description Denosumab is a human monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women with a high risk of fractures. To our knowledge, no cases of desensitization to this drug have been described in the literature. We report the first case of generalized urticarial reaction and facial angioedema after therapy with denosumab. A subcutaneous desensitization protocol was successfully completed in this patient. Rapid desensitization is a promising method for the delivery of denosumab after a hypersensitivity reaction, and should be considered in osteoporosis treatment when no acceptable therapeutic alternatives are available.
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spelling pubmed-46207162015-10-27 Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration Gutiérrez-Fernández, D. Cruz, María-Jesús Foncubierta-Fernández, A. Moreno-Ancillo, A. Fernández-Anguita, M. J. Medina-Varo, F. Andres-García, J. A. Allergy Asthma Clin Immunol Case Report Denosumab is a human monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women with a high risk of fractures. To our knowledge, no cases of desensitization to this drug have been described in the literature. We report the first case of generalized urticarial reaction and facial angioedema after therapy with denosumab. A subcutaneous desensitization protocol was successfully completed in this patient. Rapid desensitization is a promising method for the delivery of denosumab after a hypersensitivity reaction, and should be considered in osteoporosis treatment when no acceptable therapeutic alternatives are available. BioMed Central 2015-10-26 /pmc/articles/PMC4620716/ /pubmed/26504466 http://dx.doi.org/10.1186/s13223-015-0097-6 Text en © Gutiérrez-Fernández et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Gutiérrez-Fernández, D.
Cruz, María-Jesús
Foncubierta-Fernández, A.
Moreno-Ancillo, A.
Fernández-Anguita, M. J.
Medina-Varo, F.
Andres-García, J. A.
Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
title Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
title_full Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
title_fullStr Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
title_full_unstemmed Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
title_short Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
title_sort monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620716/
https://www.ncbi.nlm.nih.gov/pubmed/26504466
http://dx.doi.org/10.1186/s13223-015-0097-6
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