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Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation

Evaluation of the genetic contribution to the development of recurrent acute otitis media (rAOM) remains challenging. This study aimed to evaluate the potential association between single nucleotide polymorphisms (SNPs) in selected genes and rAOM and to analyze whether genetic variations might predi...

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Autores principales: Esposito, Susanna, Marchisio, Paola, Orenti, Annalisa, Spena, Silvia, Bianchini, Sonia, Nazzari, Erica, Rosazza, Chiara, Zampiero, Alberto, Biganzoli, Elia, Principi, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620788/
https://www.ncbi.nlm.nih.gov/pubmed/26496338
http://dx.doi.org/10.1097/MD.0000000000001860
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author Esposito, Susanna
Marchisio, Paola
Orenti, Annalisa
Spena, Silvia
Bianchini, Sonia
Nazzari, Erica
Rosazza, Chiara
Zampiero, Alberto
Biganzoli, Elia
Principi, Nicola
author_facet Esposito, Susanna
Marchisio, Paola
Orenti, Annalisa
Spena, Silvia
Bianchini, Sonia
Nazzari, Erica
Rosazza, Chiara
Zampiero, Alberto
Biganzoli, Elia
Principi, Nicola
author_sort Esposito, Susanna
collection PubMed
description Evaluation of the genetic contribution to the development of recurrent acute otitis media (rAOM) remains challenging. This study aimed to evaluate the potential association between single nucleotide polymorphisms (SNPs) in selected genes and rAOM and to analyze whether genetic variations might predispose to the development of complicated recurrent cases, such as those with tympanic membrane perforation (TMP). A total of 33 candidate genes and 47 SNPs were genotyped in 200 children with rAOM (116 with a history of TMP) and in 200 healthy controls. INFγ rs 12369470CT was significantly less common in the children with rAOM than in healthy controls (odds ratio [OR] 0.5, 95% confidence interval [CI] 0.25–1, P = 0.04). Although not significant, interleukin (IL)-1β rs 1143627G and toll-like receptor (TLR)-4 rs2737191AG were less frequently detected in the children with rAOM than in controls. The opposite was true for IL-8 rs2227306CT, which was found more frequently in the children with rAOM than in healthy controls. The IL-10 rs1800896TC SNP and the IL-1α rs6746923A and AG SNPs were significantly more and less common, respectively, among children without a history of TMP than among those who suffered from this complication (OR 2.17, 95% CI 1.09–4.41, P = 0.02, and OR 0.42, 95% CI 0.21–0.84, P = 0.01). This study is the first report suggesting an association between variants in genes encoding for factors of innate or adaptive immunity and the occurrence of rAOM with or without TMP, which confirms the role of genetics in conditioning susceptibility to AOM.
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spelling pubmed-46207882015-10-27 Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation Esposito, Susanna Marchisio, Paola Orenti, Annalisa Spena, Silvia Bianchini, Sonia Nazzari, Erica Rosazza, Chiara Zampiero, Alberto Biganzoli, Elia Principi, Nicola Medicine (Baltimore) 6000 Evaluation of the genetic contribution to the development of recurrent acute otitis media (rAOM) remains challenging. This study aimed to evaluate the potential association between single nucleotide polymorphisms (SNPs) in selected genes and rAOM and to analyze whether genetic variations might predispose to the development of complicated recurrent cases, such as those with tympanic membrane perforation (TMP). A total of 33 candidate genes and 47 SNPs were genotyped in 200 children with rAOM (116 with a history of TMP) and in 200 healthy controls. INFγ rs 12369470CT was significantly less common in the children with rAOM than in healthy controls (odds ratio [OR] 0.5, 95% confidence interval [CI] 0.25–1, P = 0.04). Although not significant, interleukin (IL)-1β rs 1143627G and toll-like receptor (TLR)-4 rs2737191AG were less frequently detected in the children with rAOM than in controls. The opposite was true for IL-8 rs2227306CT, which was found more frequently in the children with rAOM than in healthy controls. The IL-10 rs1800896TC SNP and the IL-1α rs6746923A and AG SNPs were significantly more and less common, respectively, among children without a history of TMP than among those who suffered from this complication (OR 2.17, 95% CI 1.09–4.41, P = 0.02, and OR 0.42, 95% CI 0.21–0.84, P = 0.01). This study is the first report suggesting an association between variants in genes encoding for factors of innate or adaptive immunity and the occurrence of rAOM with or without TMP, which confirms the role of genetics in conditioning susceptibility to AOM. Wolters Kluwer Health 2015-10-23 /pmc/articles/PMC4620788/ /pubmed/26496338 http://dx.doi.org/10.1097/MD.0000000000001860 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 6000
Esposito, Susanna
Marchisio, Paola
Orenti, Annalisa
Spena, Silvia
Bianchini, Sonia
Nazzari, Erica
Rosazza, Chiara
Zampiero, Alberto
Biganzoli, Elia
Principi, Nicola
Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation
title Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation
title_full Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation
title_fullStr Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation
title_full_unstemmed Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation
title_short Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation
title_sort genetic polymorphisms of functional candidate genes and recurrent acute otitis media with or without tympanic membrane perforation
topic 6000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620788/
https://www.ncbi.nlm.nih.gov/pubmed/26496338
http://dx.doi.org/10.1097/MD.0000000000001860
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