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MicroRNA-155 and Its Role in Malignant Hematopoiesis
MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Libertas Academica
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620936/ https://www.ncbi.nlm.nih.gov/pubmed/26523117 http://dx.doi.org/10.4137/BMI.S27676 |
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| author | Ranganath, Prajnya |
| author_facet | Ranganath, Prajnya |
| author_sort | Ranganath, Prajnya |
| collection | PubMed |
| description | MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and the type of malignancy. In particular, it has been strongly implicated in the causation of diffuse large B-cell lymphomas. This review focuses on the molecular interactions of miR-155, its oncogenic mechanisms, and its potential as an effective therapeutic target for the associated malignancies. |
| format | Online Article Text |
| id | pubmed-4620936 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Libertas Academica |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46209362015-10-30 MicroRNA-155 and Its Role in Malignant Hematopoiesis Ranganath, Prajnya Biomark Insights Review MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and the type of malignancy. In particular, it has been strongly implicated in the causation of diffuse large B-cell lymphomas. This review focuses on the molecular interactions of miR-155, its oncogenic mechanisms, and its potential as an effective therapeutic target for the associated malignancies. Libertas Academica 2015-10-22 /pmc/articles/PMC4620936/ /pubmed/26523117 http://dx.doi.org/10.4137/BMI.S27676 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 license. |
| spellingShingle | Review Ranganath, Prajnya MicroRNA-155 and Its Role in Malignant Hematopoiesis |
| title | MicroRNA-155 and Its Role in Malignant Hematopoiesis |
| title_full | MicroRNA-155 and Its Role in Malignant Hematopoiesis |
| title_fullStr | MicroRNA-155 and Its Role in Malignant Hematopoiesis |
| title_full_unstemmed | MicroRNA-155 and Its Role in Malignant Hematopoiesis |
| title_short | MicroRNA-155 and Its Role in Malignant Hematopoiesis |
| title_sort | microrna-155 and its role in malignant hematopoiesis |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620936/ https://www.ncbi.nlm.nih.gov/pubmed/26523117 http://dx.doi.org/10.4137/BMI.S27676 |
| work_keys_str_mv | AT ranganathprajnya microrna155anditsroleinmalignanthematopoiesis |