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Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9
The anterior pituitary releases six different hormones that control virtually all aspects of vertebrate physiology, yet the molecular mechanisms underlying their Ca(2+)-triggered release remain unknown. A subset of the synaptotagmin (syt) family of proteins serve as Ca(2+) sensors for exocytosis in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620939/ https://www.ncbi.nlm.nih.gov/pubmed/26482442 http://dx.doi.org/10.1038/ncomms9645 |
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author | Roper, Lindsey K. Briguglio, Joseph S. Evans, Chantell S. Jackson, Meyer B. Chapman, Edwin R. |
author_facet | Roper, Lindsey K. Briguglio, Joseph S. Evans, Chantell S. Jackson, Meyer B. Chapman, Edwin R. |
author_sort | Roper, Lindsey K. |
collection | PubMed |
description | The anterior pituitary releases six different hormones that control virtually all aspects of vertebrate physiology, yet the molecular mechanisms underlying their Ca(2+)-triggered release remain unknown. A subset of the synaptotagmin (syt) family of proteins serve as Ca(2+) sensors for exocytosis in neurons and neuroendocrine cells, and are thus likely to regulate pituitary hormone secretion. Here we show that numerous syt isoforms are highly expressed in the pituitary gland in a lobe, and sex-specific manner. We further investigated a Ca(2+)-activated isoform, syt-9, and found that it is expressed in a subpopulation of anterior pituitary cells, the gonadotropes. Follicle-stimulating hormone (FSH) and syt-9 are highly co-localized in female, but not male, mice. Loss of syt-9 results in diminished basal and stimulated FSH secretion only in females, resulting in alterations in the oestrus cycle. This work uncovers a new function for syt-9 and reveals a novel sex difference in reproductive hormone secretion. |
format | Online Article Text |
id | pubmed-4620939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46209392015-12-10 Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 Roper, Lindsey K. Briguglio, Joseph S. Evans, Chantell S. Jackson, Meyer B. Chapman, Edwin R. Nat Commun Article The anterior pituitary releases six different hormones that control virtually all aspects of vertebrate physiology, yet the molecular mechanisms underlying their Ca(2+)-triggered release remain unknown. A subset of the synaptotagmin (syt) family of proteins serve as Ca(2+) sensors for exocytosis in neurons and neuroendocrine cells, and are thus likely to regulate pituitary hormone secretion. Here we show that numerous syt isoforms are highly expressed in the pituitary gland in a lobe, and sex-specific manner. We further investigated a Ca(2+)-activated isoform, syt-9, and found that it is expressed in a subpopulation of anterior pituitary cells, the gonadotropes. Follicle-stimulating hormone (FSH) and syt-9 are highly co-localized in female, but not male, mice. Loss of syt-9 results in diminished basal and stimulated FSH secretion only in females, resulting in alterations in the oestrus cycle. This work uncovers a new function for syt-9 and reveals a novel sex difference in reproductive hormone secretion. Nature Pub. Group 2015-10-20 /pmc/articles/PMC4620939/ /pubmed/26482442 http://dx.doi.org/10.1038/ncomms9645 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Roper, Lindsey K. Briguglio, Joseph S. Evans, Chantell S. Jackson, Meyer B. Chapman, Edwin R. Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 |
title | Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 |
title_full | Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 |
title_fullStr | Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 |
title_full_unstemmed | Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 |
title_short | Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 |
title_sort | sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620939/ https://www.ncbi.nlm.nih.gov/pubmed/26482442 http://dx.doi.org/10.1038/ncomms9645 |
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