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Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma
BACKGROUND: Skull calvarium and dura mater are rare sites of distant metastasis, and mostly have been reported in lung, breast, and prostate malignancies. However, the calvarial and dural metastases from papillary thyroid cancer (PTC) are rare entities and pose diagnostic and therapeutic challenges....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621188/ https://www.ncbi.nlm.nih.gov/pubmed/26527901 http://dx.doi.org/10.2147/IMCRJ.S86183 |
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author | AL-Qahtani, Khalid Hussain Tunio, Mutahir A Al Asiri, Mushabbab Fatani, Hanadi Bayoumi, Yasser |
author_facet | AL-Qahtani, Khalid Hussain Tunio, Mutahir A Al Asiri, Mushabbab Fatani, Hanadi Bayoumi, Yasser |
author_sort | AL-Qahtani, Khalid Hussain |
collection | PubMed |
description | BACKGROUND: Skull calvarium and dura mater are rare sites of distant metastasis, and mostly have been reported in lung, breast, and prostate malignancies. However, the calvarial and dural metastases from papillary thyroid cancer (PTC) are rare entities and pose diagnostic and therapeutic challenges. To date, only seven cases of calvarial metastasis with intracranial extension from PTC have been reported in literature. However, true dural metastasis from PTC has not yet been reported. CASE PRESENTATION: A 65-year-old Saudi woman presented with 6 months history of painful posterior scalp lump, 7 years after initial diagnosis of PTC. Computed tomography and magnetic resonance imaging showed occipitoparietal calvarial lesion with massive intracranial extension. Another para-sagittal lesion was found at the top of corpus callosum mimicking a meningioma. Histopathology of para-sagittal lesion and the biopsy of calvarial mass confirmed the diagnosis of metastatic PTC. After surgical resection, residual tumors were treated with postoperative intensity-modulated radiation therapy. At 13 months of follow-up, patient was alive and without any signs of recurrence. CONCLUSION: Calvarial and dural metastases from PTC are extremely rare clinical entities. Surgical resection followed by postoperative radiotherapy is the treatment of choice. However, for such cases, multidisciplinary approach can prolong the treatment outcome and survival. |
format | Online Article Text |
id | pubmed-4621188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46211882015-11-02 Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma AL-Qahtani, Khalid Hussain Tunio, Mutahir A Al Asiri, Mushabbab Fatani, Hanadi Bayoumi, Yasser Int Med Case Rep J Case Report BACKGROUND: Skull calvarium and dura mater are rare sites of distant metastasis, and mostly have been reported in lung, breast, and prostate malignancies. However, the calvarial and dural metastases from papillary thyroid cancer (PTC) are rare entities and pose diagnostic and therapeutic challenges. To date, only seven cases of calvarial metastasis with intracranial extension from PTC have been reported in literature. However, true dural metastasis from PTC has not yet been reported. CASE PRESENTATION: A 65-year-old Saudi woman presented with 6 months history of painful posterior scalp lump, 7 years after initial diagnosis of PTC. Computed tomography and magnetic resonance imaging showed occipitoparietal calvarial lesion with massive intracranial extension. Another para-sagittal lesion was found at the top of corpus callosum mimicking a meningioma. Histopathology of para-sagittal lesion and the biopsy of calvarial mass confirmed the diagnosis of metastatic PTC. After surgical resection, residual tumors were treated with postoperative intensity-modulated radiation therapy. At 13 months of follow-up, patient was alive and without any signs of recurrence. CONCLUSION: Calvarial and dural metastases from PTC are extremely rare clinical entities. Surgical resection followed by postoperative radiotherapy is the treatment of choice. However, for such cases, multidisciplinary approach can prolong the treatment outcome and survival. Dove Medical Press 2015-10-16 /pmc/articles/PMC4621188/ /pubmed/26527901 http://dx.doi.org/10.2147/IMCRJ.S86183 Text en © 2015 AL-Qahtani et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report AL-Qahtani, Khalid Hussain Tunio, Mutahir A Al Asiri, Mushabbab Fatani, Hanadi Bayoumi, Yasser Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma |
title | Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma |
title_full | Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma |
title_fullStr | Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma |
title_full_unstemmed | Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma |
title_short | Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma |
title_sort | calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621188/ https://www.ncbi.nlm.nih.gov/pubmed/26527901 http://dx.doi.org/10.2147/IMCRJ.S86183 |
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