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4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression

BACKGROUND: Obesity-associated insulin resistance (IR) is highly correlated with soluble tumor necrosis factor-α (sTNF-α), which is released from transmembranous TNF-α by TNF-α converting enzyme (TACE). In vivo, TACE activity is suppressed by tissue inhibitor of metalloproteinase 3 (TIMP3). Agents t...

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Detalles Bibliográficos
Autores principales:	Gao, Feng, Du, Wen, Zafar, Mohammad Ishraq, Shafqat, Raja Adeel, Jian, Liumeng, Cai, Qin, Lu, Furong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621195/ https://www.ncbi.nlm.nih.gov/pubmed/26527864 http://dx.doi.org/10.2147/DDDT.S92355

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