Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion

Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is genera...

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Detalles Bibliográficos
Autores principales: Russell, Jason L., Spiller, Henry A., Baker, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621337/
https://www.ncbi.nlm.nih.gov/pubmed/26550016
http://dx.doi.org/10.1155/2015/369707
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author Russell, Jason L.
Spiller, Henry A.
Baker, Daniel D.
author_facet Russell, Jason L.
Spiller, Henry A.
Baker, Daniel D.
author_sort Russell, Jason L.
collection PubMed
description Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxide metabolite concentration was found to be 450% higher than the parent compound, suggesting a potential role for metabolite quantification in severe toxicity.
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spelling pubmed-46213372015-11-08 Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion Russell, Jason L. Spiller, Henry A. Baker, Daniel D. Case Rep Med Case Report Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxide metabolite concentration was found to be 450% higher than the parent compound, suggesting a potential role for metabolite quantification in severe toxicity. Hindawi Publishing Corporation 2015 2015-10-13 /pmc/articles/PMC4621337/ /pubmed/26550016 http://dx.doi.org/10.1155/2015/369707 Text en Copyright © 2015 Jason L. Russell et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Russell, Jason L.
Spiller, Henry A.
Baker, Daniel D.
Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
title Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
title_full Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
title_fullStr Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
title_full_unstemmed Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
title_short Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
title_sort markedly elevated carbamazepine-10,11-epoxide/carbamazepine ratio in a fatal carbamazepine ingestion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621337/
https://www.ncbi.nlm.nih.gov/pubmed/26550016
http://dx.doi.org/10.1155/2015/369707
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AT spillerhenrya markedlyelevatedcarbamazepine1011epoxidecarbamazepineratioinafatalcarbamazepineingestion
AT bakerdanield markedlyelevatedcarbamazepine1011epoxidecarbamazepineratioinafatalcarbamazepineingestion

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