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Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the sm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621380/ https://www.ncbi.nlm.nih.gov/pubmed/26402456 http://dx.doi.org/10.7554/eLife.08827 |
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author | Martik, Megan L McClay, David R |
author_facet | Martik, Megan L McClay, David R |
author_sort | Martik, Megan L |
collection | PubMed |
description | Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the small micromeres to the coelomic pouches in the sea urchin embryo provides an exceptional model for understanding the genomic regulatory control of morphogenesis. An assay using the robust homing potential of these cells reveals a ‘coherent feed-forward’ transcriptional subcircuit composed of Pax6, Six3, Six1/2, Eya, and Dach1 that is responsible for the directed homing mechanism of these multipotent progenitors. The linkages of that circuit are strikingly similar to a circuit involved in retinal specification in Drosophila suggesting that systems-level tasks can be highly conserved even though the tasks drive unrelated processes in different animals. DOI: http://dx.doi.org/10.7554/eLife.08827.001 |
format | Online Article Text |
id | pubmed-4621380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46213802015-10-28 Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo Martik, Megan L McClay, David R eLife Developmental Biology and Stem Cells Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the small micromeres to the coelomic pouches in the sea urchin embryo provides an exceptional model for understanding the genomic regulatory control of morphogenesis. An assay using the robust homing potential of these cells reveals a ‘coherent feed-forward’ transcriptional subcircuit composed of Pax6, Six3, Six1/2, Eya, and Dach1 that is responsible for the directed homing mechanism of these multipotent progenitors. The linkages of that circuit are strikingly similar to a circuit involved in retinal specification in Drosophila suggesting that systems-level tasks can be highly conserved even though the tasks drive unrelated processes in different animals. DOI: http://dx.doi.org/10.7554/eLife.08827.001 eLife Sciences Publications, Ltd 2015-09-24 /pmc/articles/PMC4621380/ /pubmed/26402456 http://dx.doi.org/10.7554/eLife.08827 Text en © 2015, Martik and McClay http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology and Stem Cells Martik, Megan L McClay, David R Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
title | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
title_full | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
title_fullStr | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
title_full_unstemmed | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
title_short | Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
title_sort | deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo |
topic | Developmental Biology and Stem Cells |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621380/ https://www.ncbi.nlm.nih.gov/pubmed/26402456 http://dx.doi.org/10.7554/eLife.08827 |
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