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Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo

Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the sm...

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Autores principales: Martik, Megan L, McClay, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621380/
https://www.ncbi.nlm.nih.gov/pubmed/26402456
http://dx.doi.org/10.7554/eLife.08827
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author Martik, Megan L
McClay, David R
author_facet Martik, Megan L
McClay, David R
author_sort Martik, Megan L
collection PubMed
description Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the small micromeres to the coelomic pouches in the sea urchin embryo provides an exceptional model for understanding the genomic regulatory control of morphogenesis. An assay using the robust homing potential of these cells reveals a ‘coherent feed-forward’ transcriptional subcircuit composed of Pax6, Six3, Six1/2, Eya, and Dach1 that is responsible for the directed homing mechanism of these multipotent progenitors. The linkages of that circuit are strikingly similar to a circuit involved in retinal specification in Drosophila suggesting that systems-level tasks can be highly conserved even though the tasks drive unrelated processes in different animals. DOI: http://dx.doi.org/10.7554/eLife.08827.001
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spelling pubmed-46213802015-10-28 Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo Martik, Megan L McClay, David R eLife Developmental Biology and Stem Cells Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism's genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the small micromeres to the coelomic pouches in the sea urchin embryo provides an exceptional model for understanding the genomic regulatory control of morphogenesis. An assay using the robust homing potential of these cells reveals a ‘coherent feed-forward’ transcriptional subcircuit composed of Pax6, Six3, Six1/2, Eya, and Dach1 that is responsible for the directed homing mechanism of these multipotent progenitors. The linkages of that circuit are strikingly similar to a circuit involved in retinal specification in Drosophila suggesting that systems-level tasks can be highly conserved even though the tasks drive unrelated processes in different animals. DOI: http://dx.doi.org/10.7554/eLife.08827.001 eLife Sciences Publications, Ltd 2015-09-24 /pmc/articles/PMC4621380/ /pubmed/26402456 http://dx.doi.org/10.7554/eLife.08827 Text en © 2015, Martik and McClay http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology and Stem Cells
Martik, Megan L
McClay, David R
Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
title Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
title_full Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
title_fullStr Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
title_full_unstemmed Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
title_short Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
title_sort deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo
topic Developmental Biology and Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621380/
https://www.ncbi.nlm.nih.gov/pubmed/26402456
http://dx.doi.org/10.7554/eLife.08827
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