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Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test
The assessment of motor and executive functions following stroke or traumatic brain injury is a key aspect of impairment evaluation and used to guide further therapy. In clinical routine, such assessments are largely dominated by pen-and-paper tests. While these provide standardized, reliable, and e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621429/ https://www.ncbi.nlm.nih.gov/pubmed/26579066 http://dx.doi.org/10.3389/fneur.2015.00219 |
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author | Camilleri, Julia A. Reid, Andrew T. Müller, Veronika I. Grefkes, Christian Amunts, Katrin Eickhoff, Simon B. |
author_facet | Camilleri, Julia A. Reid, Andrew T. Müller, Veronika I. Grefkes, Christian Amunts, Katrin Eickhoff, Simon B. |
author_sort | Camilleri, Julia A. |
collection | PubMed |
description | The assessment of motor and executive functions following stroke or traumatic brain injury is a key aspect of impairment evaluation and used to guide further therapy. In clinical routine, such assessments are largely dominated by pen-and-paper tests. While these provide standardized, reliable, and ecologically valid measures of the individual level of functioning, rather little is yet known about their neurobiological underpinnings. Therefore, the aim of this study was to investigate brain regions and their associated networks that are related to upper extremity motor function, as quantified by the motor speed subtest of the trail making test (TMT-MS). Whole-brain voxel-based morphometry and whole-brain tract-based spatial statistics were used to investigate the association between TMT-MS performance with gray-matter volume (GMV) and white-matter integrity, respectively. While results demonstrated no relationship to local white-matter properties, we found a significant correlation between TMT-MS performance and GMV of the lower bank of the inferior frontal sulcus, a region associated with cognitive processing, as indicated by assessing its functional profile by the BrainMap database. Using this finding as a seed region, we further examined and compared networks as reflected by resting state connectivity, meta-analytic connectivity modeling, structural covariance, and probabilistic tractography. While differences between the different approaches were observed, all approaches converged on a network comprising regions that overlap with the multiple-demand network. Our data therefore indicate that performance may primarily depend on executive function, thus suggesting that motor speed in a more naturalistic setting should be more associated with executive rather than primary motor function. Moreover, results showed that while there were differences between the approaches, a convergence indicated that common networks can be revealed across highly divergent methods. |
format | Online Article Text |
id | pubmed-4621429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46214292015-11-17 Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test Camilleri, Julia A. Reid, Andrew T. Müller, Veronika I. Grefkes, Christian Amunts, Katrin Eickhoff, Simon B. Front Neurol Neuroscience The assessment of motor and executive functions following stroke or traumatic brain injury is a key aspect of impairment evaluation and used to guide further therapy. In clinical routine, such assessments are largely dominated by pen-and-paper tests. While these provide standardized, reliable, and ecologically valid measures of the individual level of functioning, rather little is yet known about their neurobiological underpinnings. Therefore, the aim of this study was to investigate brain regions and their associated networks that are related to upper extremity motor function, as quantified by the motor speed subtest of the trail making test (TMT-MS). Whole-brain voxel-based morphometry and whole-brain tract-based spatial statistics were used to investigate the association between TMT-MS performance with gray-matter volume (GMV) and white-matter integrity, respectively. While results demonstrated no relationship to local white-matter properties, we found a significant correlation between TMT-MS performance and GMV of the lower bank of the inferior frontal sulcus, a region associated with cognitive processing, as indicated by assessing its functional profile by the BrainMap database. Using this finding as a seed region, we further examined and compared networks as reflected by resting state connectivity, meta-analytic connectivity modeling, structural covariance, and probabilistic tractography. While differences between the different approaches were observed, all approaches converged on a network comprising regions that overlap with the multiple-demand network. Our data therefore indicate that performance may primarily depend on executive function, thus suggesting that motor speed in a more naturalistic setting should be more associated with executive rather than primary motor function. Moreover, results showed that while there were differences between the approaches, a convergence indicated that common networks can be revealed across highly divergent methods. Frontiers Media S.A. 2015-10-27 /pmc/articles/PMC4621429/ /pubmed/26579066 http://dx.doi.org/10.3389/fneur.2015.00219 Text en Copyright © 2015 Camilleri, Reid, Müller, Grefkes, Amunts and Eickhoff. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Camilleri, Julia A. Reid, Andrew T. Müller, Veronika I. Grefkes, Christian Amunts, Katrin Eickhoff, Simon B. Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test |
title | Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test |
title_full | Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test |
title_fullStr | Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test |
title_full_unstemmed | Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test |
title_short | Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test |
title_sort | multi-modal imaging of neural correlates of motor speed performance in the trail making test |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621429/ https://www.ncbi.nlm.nih.gov/pubmed/26579066 http://dx.doi.org/10.3389/fneur.2015.00219 |
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