The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples

Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific fo...

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Autores principales: Vandepoele, Karl, Philippé, Jan, Denys, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621498/
https://www.ncbi.nlm.nih.gov/pubmed/26605151
http://dx.doi.org/10.1016/j.lrr.2015.07.001
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author Vandepoele, Karl
Philippé, Jan
Denys, Barbara
author_facet Vandepoele, Karl
Philippé, Jan
Denys, Barbara
author_sort Vandepoele, Karl
collection PubMed
description Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.
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spelling pubmed-46214982015-11-24 The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples Vandepoele, Karl Philippé, Jan Denys, Barbara Leuk Res Rep Case Report Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease. Elsevier 2015-08-06 /pmc/articles/PMC4621498/ /pubmed/26605151 http://dx.doi.org/10.1016/j.lrr.2015.07.001 Text en © 2015 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Vandepoele, Karl
Philippé, Jan
Denys, Barbara
The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
title The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
title_full The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
title_fullStr The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
title_full_unstemmed The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
title_short The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
title_sort ypel5–ppp1cb fusion transcript is detected in different hematological malignancies and in normal samples
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621498/
https://www.ncbi.nlm.nih.gov/pubmed/26605151
http://dx.doi.org/10.1016/j.lrr.2015.07.001
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