Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

[Image: see text] The bifunctional enzyme N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclo hydrolase (FolD) is essential for growth in Trypanosomatidae. We sought to develop inhibitors of Trypanosoma brucei FolD (TbFolD) as potential antiparasitic agents. Compound 2 was synthesized, and the...

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Detalles Bibliográficos
Autores principales: Eadsforth, Thomas C., Pinto, Andrea, Luciani, Rosaria, Tamborini, Lucia, Cullia, Gregorio, De Micheli, Carlo, Marinelli, Luciana, Cosconati, Sandro, Novellino, Ettore, Lo Presti, Leonardo, Cordeiro da Silva, Anabela, Conti, Paola, Hunter, William N., Costi, Maria P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621507/
https://www.ncbi.nlm.nih.gov/pubmed/26322631
http://dx.doi.org/10.1021/acs.jmedchem.5b00687

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