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Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis

The small G protein Arf6 and the GTPase dynamin2 (Dyn2) play key roles in clathrin-mediated endocytosis (CME). However, their functional relationship remains obscure. Here, we show that Arf6 functions as a downstream molecule of Dyn2 in CME. Wild type of Dyn2 overexpressed in HeLa cells markedly act...

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Detalles Bibliográficos
Autores principales:	Okada, Risa, Yamauchi, Yohei, Hongu, Tsunaki, Funakoshi, Yuji, Ohbayashi, Norihiko, Hasegawa, Hiroshi, Kanaho, Yasunori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621509/ https://www.ncbi.nlm.nih.gov/pubmed/26503427 http://dx.doi.org/10.1038/srep14919

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