Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952

Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3...

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Autores principales: Vujkovic, Marijana, Kershenbaum, Aaron, Wray, Lisa, McWilliams, Thomas, Cannon, Shannon, Devidas, Meenakshi, Stork, Linda, Aplenc, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621538/
https://www.ncbi.nlm.nih.gov/pubmed/26605150
http://dx.doi.org/10.1016/j.lrr.2015.05.005
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author Vujkovic, Marijana
Kershenbaum, Aaron
Wray, Lisa
McWilliams, Thomas
Cannon, Shannon
Devidas, Meenakshi
Stork, Linda
Aplenc, Richard
author_facet Vujkovic, Marijana
Kershenbaum, Aaron
Wray, Lisa
McWilliams, Thomas
Cannon, Shannon
Devidas, Meenakshi
Stork, Linda
Aplenc, Richard
author_sort Vujkovic, Marijana
collection PubMed
description Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3, 95%CI 1.2–8.6; rs2842947, OR 2.7, 95%CI 1.1–6.8; rs2842935, OR 2.5, 95%CI 1.1–5.0; rs10925235, OR 4.9, 95%CI 1.1–25.1). One variant in SLC19A1 showed a protective effect (rs4819128, OR 0.5, 95%CI 0.3–0.9). Our study provides data that relapse risk in pediatric ALL is associated with germline variations in TPMT, MTR and SLC19A1.
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spelling pubmed-46215382015-11-24 Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952 Vujkovic, Marijana Kershenbaum, Aaron Wray, Lisa McWilliams, Thomas Cannon, Shannon Devidas, Meenakshi Stork, Linda Aplenc, Richard Leuk Res Rep Article Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3, 95%CI 1.2–8.6; rs2842947, OR 2.7, 95%CI 1.1–6.8; rs2842935, OR 2.5, 95%CI 1.1–5.0; rs10925235, OR 4.9, 95%CI 1.1–25.1). One variant in SLC19A1 showed a protective effect (rs4819128, OR 0.5, 95%CI 0.3–0.9). Our study provides data that relapse risk in pediatric ALL is associated with germline variations in TPMT, MTR and SLC19A1. Elsevier 2015-07-21 /pmc/articles/PMC4621538/ /pubmed/26605150 http://dx.doi.org/10.1016/j.lrr.2015.05.005 Text en © 2015 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Vujkovic, Marijana
Kershenbaum, Aaron
Wray, Lisa
McWilliams, Thomas
Cannon, Shannon
Devidas, Meenakshi
Stork, Linda
Aplenc, Richard
Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
title Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
title_full Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
title_fullStr Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
title_full_unstemmed Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
title_short Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
title_sort associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on ccg-1952
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621538/
https://www.ncbi.nlm.nih.gov/pubmed/26605150
http://dx.doi.org/10.1016/j.lrr.2015.05.005
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