Cargando…
Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats
OBJECTIVES: The aim of the present study was to investigate the anti-osteoporotic activity of Maxcal-C in ovariectomy (OVX)-induced osteoporosis in rats. MATERIALS AND METHODS: Sham-operated control rats were designated as Group I; Group II animals served as OVX control; Group III OVX control rats t...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621680/ https://www.ncbi.nlm.nih.gov/pubmed/26600648 http://dx.doi.org/10.4103/0253-7613.165185 |
_version_ | 1782397477686607872 |
---|---|
author | Maheshwari, Rajesh A. Dhakwala, Falak Balaraman, R. Seth, Avinash K. Soni, Hardik Patel, Ghanshyam |
author_facet | Maheshwari, Rajesh A. Dhakwala, Falak Balaraman, R. Seth, Avinash K. Soni, Hardik Patel, Ghanshyam |
author_sort | Maheshwari, Rajesh A. |
collection | PubMed |
description | OBJECTIVES: The aim of the present study was to investigate the anti-osteoporotic activity of Maxcal-C in ovariectomy (OVX)-induced osteoporosis in rats. MATERIALS AND METHODS: Sham-operated control rats were designated as Group I; Group II animals served as OVX control; Group III OVX control rats treated with Calcium Sandoz (50 mg/kg, p.o.); Group IV and V OVX control rats treated with Maxcal-C (250 and 500 mg/kg, p.o.), respectively. All the aforementioned treatments were given for four weeks after the development of osteoporosis. At the end of the treatment, serum biochemical parameters such as serum calcium and alkaline phosphate were measured. After sacrificing the animals, femoral bone parameters with histology, body weight, and bone breaking strength of 5(th) lumbar vertebra were measured. RESULTS: The treatment with Maxcal-C showed a significant improvement in serum biochemical, femoral bone parameters, and bone breaking strength of 5(th) lumbar vertebra with histopathological changes. CONCLUSION: The finding of the present study indicates that Maxcal-C showed a potential anti-osteoporotic activity. These results support the traditional use of Maxcal-C in the treatment of osteoporosis. |
format | Online Article Text |
id | pubmed-4621680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46216802015-11-23 Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats Maheshwari, Rajesh A. Dhakwala, Falak Balaraman, R. Seth, Avinash K. Soni, Hardik Patel, Ghanshyam Indian J Pharmacol Short Communication OBJECTIVES: The aim of the present study was to investigate the anti-osteoporotic activity of Maxcal-C in ovariectomy (OVX)-induced osteoporosis in rats. MATERIALS AND METHODS: Sham-operated control rats were designated as Group I; Group II animals served as OVX control; Group III OVX control rats treated with Calcium Sandoz (50 mg/kg, p.o.); Group IV and V OVX control rats treated with Maxcal-C (250 and 500 mg/kg, p.o.), respectively. All the aforementioned treatments were given for four weeks after the development of osteoporosis. At the end of the treatment, serum biochemical parameters such as serum calcium and alkaline phosphate were measured. After sacrificing the animals, femoral bone parameters with histology, body weight, and bone breaking strength of 5(th) lumbar vertebra were measured. RESULTS: The treatment with Maxcal-C showed a significant improvement in serum biochemical, femoral bone parameters, and bone breaking strength of 5(th) lumbar vertebra with histopathological changes. CONCLUSION: The finding of the present study indicates that Maxcal-C showed a potential anti-osteoporotic activity. These results support the traditional use of Maxcal-C in the treatment of osteoporosis. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4621680/ /pubmed/26600648 http://dx.doi.org/10.4103/0253-7613.165185 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Short Communication Maheshwari, Rajesh A. Dhakwala, Falak Balaraman, R. Seth, Avinash K. Soni, Hardik Patel, Ghanshyam Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats |
title | Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats |
title_full | Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats |
title_fullStr | Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats |
title_full_unstemmed | Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats |
title_short | Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats |
title_sort | maxcal-c (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621680/ https://www.ncbi.nlm.nih.gov/pubmed/26600648 http://dx.doi.org/10.4103/0253-7613.165185 |
work_keys_str_mv | AT maheshwarirajesha maxcalcapolyherbalformulationpreventsovariectomyinducedosteoporosisinrats AT dhakwalafalak maxcalcapolyherbalformulationpreventsovariectomyinducedosteoporosisinrats AT balaramanr maxcalcapolyherbalformulationpreventsovariectomyinducedosteoporosisinrats AT sethavinashk maxcalcapolyherbalformulationpreventsovariectomyinducedosteoporosisinrats AT sonihardik maxcalcapolyherbalformulationpreventsovariectomyinducedosteoporosisinrats AT patelghanshyam maxcalcapolyherbalformulationpreventsovariectomyinducedosteoporosisinrats |