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Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hH(V)1

Part of the “signature sequence” that defines the voltage-gated proton channel (H(V)1) is a tryptophan residue adjacent to the second Arg in the S4 transmembrane helix: RxWRxxR, which is perfectly conserved in all high confidence H(V)1 genes. Replacing Trp(207) in human H(V)1 (hH(V)1) with Ala, Ser,...

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Detalles Bibliográficos
Autores principales:	Cherny, Vladimir V., Morgan, Deri, Musset, Boris, Chaves, Gustavo, Smith, Susan M.E., DeCoursey, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621752/ https://www.ncbi.nlm.nih.gov/pubmed/26458876 http://dx.doi.org/10.1085/jgp.201511456

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