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A Coiled-Coil Mimetic Intercepts BCR-ABL1 Dimerization in Native and Kinase-Mutant Chronic Myeloid Leukemia

Targeted therapy of chronic myeloid leukemia is currently based on small-molecule inhibitors that directly bind the tyrosine kinase domain of BCR-ABL1. This strategy has generally been successful, but is subject to drug resistance due to point mutations in the kinase domain. Kinase activity requires...

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Detalles Bibliográficos
Autores principales:	Woessner, David W., Eiring, Anna M., Bruno, Benjamin J., Zabriskie, Matthew S., Reynolds, Kimberly R., Miller, Geoffrey D., O’Hare, Thomas, Deininger, Michael W., Lim, Carol S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621806/ https://www.ncbi.nlm.nih.gov/pubmed/25721898 http://dx.doi.org/10.1038/leu.2015.53

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