MT1-MMP: Endosomal delivery drives breast cancer metastasis

The membrane-tethered membrane type 1–matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endos...

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Detalles Bibliográficos
Autor principal: Linder, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621844/
https://www.ncbi.nlm.nih.gov/pubmed/26504163
http://dx.doi.org/10.1083/jcb.201510009
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author Linder, Stefan
author_facet Linder, Stefan
author_sort Linder, Stefan
collection PubMed
description The membrane-tethered membrane type 1–matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.
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spelling pubmed-46218442016-04-26 MT1-MMP: Endosomal delivery drives breast cancer metastasis Linder, Stefan J Cell Biol Reviews The membrane-tethered membrane type 1–matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis. The Rockefeller University Press 2015-10-26 /pmc/articles/PMC4621844/ /pubmed/26504163 http://dx.doi.org/10.1083/jcb.201510009 Text en © 2015 Linder This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Linder, Stefan
MT1-MMP: Endosomal delivery drives breast cancer metastasis
title MT1-MMP: Endosomal delivery drives breast cancer metastasis
title_full MT1-MMP: Endosomal delivery drives breast cancer metastasis
title_fullStr MT1-MMP: Endosomal delivery drives breast cancer metastasis
title_full_unstemmed MT1-MMP: Endosomal delivery drives breast cancer metastasis
title_short MT1-MMP: Endosomal delivery drives breast cancer metastasis
title_sort mt1-mmp: endosomal delivery drives breast cancer metastasis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621844/
https://www.ncbi.nlm.nih.gov/pubmed/26504163
http://dx.doi.org/10.1083/jcb.201510009
work_keys_str_mv AT linderstefan mt1mmpendosomaldeliverydrivesbreastcancermetastasis

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