Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivo

BACKGROUND: Malignant melanoma is an aggressive type of skin cancer, and despite recent advances in treatment, the survival rate of the metastatic form remains low. Nifuroxazide analogues are drugs based on the substitution of the nitrofuran group by benzofuroxan, in view of the pharmacophore simila...

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Detalles Bibliográficos
Autores principales: Farias, C. F., Massaoka, M. H., Girola, N., Azevedo, R. A., Ferreira, A. K., Jorge, S. D., Tavares, L. C., Figueiredo, C. R., Travassos, L. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621849/
https://www.ncbi.nlm.nih.gov/pubmed/26503030
http://dx.doi.org/10.1186/s12885-015-1835-3

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