Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors

Most solid tumors contain a subfraction of cells with stem/progenitor cell features. Stem cells are naturally chemoresistant suggesting that chronic chemotherapeutic stress may select for cells with increased “stemness”. We carried out a comprehensive molecular and functional analysis of six indepen...

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Detalles Bibliográficos
Autores principales: Ayadi, Meriam, Bouygues, Anaïs, Ouaret, Djamila, Ferrand, Nathalie, Chouaib, Salem, Thiery, Jean-Paul, Muchardt, Christian, Sabbah, Michèle, Larsen, Annette K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621907/
https://www.ncbi.nlm.nih.gov/pubmed/26041882

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