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Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

BACKGROUND: The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and cl...

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Autores principales: Rodríguez-Berriguete, Gonzalo, Torrealba, Norelia, Ortega, Miguel Angel, Martínez-Onsurbe, Pilar, Olmedilla, Gabriel, Paniagua, Ricardo, Guil-Cid, Manuel, Fraile, Benito, Royuela, Mar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621951/
https://www.ncbi.nlm.nih.gov/pubmed/26507126
http://dx.doi.org/10.1186/s12885-015-1839-z
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author Rodríguez-Berriguete, Gonzalo
Torrealba, Norelia
Ortega, Miguel Angel
Martínez-Onsurbe, Pilar
Olmedilla, Gabriel
Paniagua, Ricardo
Guil-Cid, Manuel
Fraile, Benito
Royuela, Mar
author_facet Rodríguez-Berriguete, Gonzalo
Torrealba, Norelia
Ortega, Miguel Angel
Martínez-Onsurbe, Pilar
Olmedilla, Gabriel
Paniagua, Ricardo
Guil-Cid, Manuel
Fraile, Benito
Royuela, Mar
author_sort Rodríguez-Berriguete, Gonzalo
collection PubMed
description BACKGROUND: The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and clinicopathological features of prostate cancer – clinical and pathological T stage, Gleason score, preoperative serum PSA levels, perineural invasion, lymph node involvement, surgical margin status and overall survival – and evaluated its capability to predict biochemical progression after radical prostatectomy. METHODS: Protein expression of caspases (procaspase-8, cleaved caspase-8, procaspase-3, cleaved caspase-3, caspase-7 and procaspase-9) and IAPs (cIAP1/2, cIAP2, NAIP, Survivin and XIAP) was analyzed by immunohistochemistry in radical prostatectomy samples from 84 prostate cancer patients. Spearman’s test, Kaplan-Meier curves, and univariate and multivariate Cox proportional hazard regression analysis were performed. RESULTS: cIAP1/2, cIAP2, Survivin, procaspase-8, cleaved caspase-8, procaspase-3 and caspase-7 expression correlated with at least one clinicopathological feature of the disease. Patients negative for XIAP, procaspase-3 or cleaved caspase-3 had a significantly worse prognosis. Of note, XIAP, procaspase-3 and cleaved caspase-3 were predictors of biochemical progression independent of Gleason score and pathological T stage. CONCLUSIONS: Our results indicate that alterations in the expression of IAPs and caspases contribute to the malignant behavior of prostate tumors and suggest that tumor expression of XIAP, procaspase-3 and cleaved caspase-3 may help to identify prostate cancer patients at risk of progression.
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spelling pubmed-46219512015-10-28 Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy Rodríguez-Berriguete, Gonzalo Torrealba, Norelia Ortega, Miguel Angel Martínez-Onsurbe, Pilar Olmedilla, Gabriel Paniagua, Ricardo Guil-Cid, Manuel Fraile, Benito Royuela, Mar BMC Cancer Research Article BACKGROUND: The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and clinicopathological features of prostate cancer – clinical and pathological T stage, Gleason score, preoperative serum PSA levels, perineural invasion, lymph node involvement, surgical margin status and overall survival – and evaluated its capability to predict biochemical progression after radical prostatectomy. METHODS: Protein expression of caspases (procaspase-8, cleaved caspase-8, procaspase-3, cleaved caspase-3, caspase-7 and procaspase-9) and IAPs (cIAP1/2, cIAP2, NAIP, Survivin and XIAP) was analyzed by immunohistochemistry in radical prostatectomy samples from 84 prostate cancer patients. Spearman’s test, Kaplan-Meier curves, and univariate and multivariate Cox proportional hazard regression analysis were performed. RESULTS: cIAP1/2, cIAP2, Survivin, procaspase-8, cleaved caspase-8, procaspase-3 and caspase-7 expression correlated with at least one clinicopathological feature of the disease. Patients negative for XIAP, procaspase-3 or cleaved caspase-3 had a significantly worse prognosis. Of note, XIAP, procaspase-3 and cleaved caspase-3 were predictors of biochemical progression independent of Gleason score and pathological T stage. CONCLUSIONS: Our results indicate that alterations in the expression of IAPs and caspases contribute to the malignant behavior of prostate tumors and suggest that tumor expression of XIAP, procaspase-3 and cleaved caspase-3 may help to identify prostate cancer patients at risk of progression. BioMed Central 2015-10-27 /pmc/articles/PMC4621951/ /pubmed/26507126 http://dx.doi.org/10.1186/s12885-015-1839-z Text en © Rodríguez-Berriguete et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rodríguez-Berriguete, Gonzalo
Torrealba, Norelia
Ortega, Miguel Angel
Martínez-Onsurbe, Pilar
Olmedilla, Gabriel
Paniagua, Ricardo
Guil-Cid, Manuel
Fraile, Benito
Royuela, Mar
Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
title Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
title_full Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
title_fullStr Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
title_full_unstemmed Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
title_short Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
title_sort prognostic value of inhibitors of apoptosis proteins (iaps) and caspases in prostate cancer: caspase-3 forms and xiap predict biochemical progression after radical prostatectomy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621951/
https://www.ncbi.nlm.nih.gov/pubmed/26507126
http://dx.doi.org/10.1186/s12885-015-1839-z
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