δ Subunit‐containing GABA(A) receptors are preferred targets for the centrally acting analgesic flupirtine

BACKGROUND AND PURPOSE: The K(v)7 channel activator flupirtine is a clinical analgesic characterized as ‘selective neuronal potassium channel opener’. Flupirtine was found to exert comparable actions at GABA(A) receptors and K(v)7 channels in neurons of pain pathways, but not in hippocampus. EXPERIM...

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Detalles Bibliográficos
Autores principales: Klinger, Felicia, Bajric, Mirnes, Salzer, Isabella, Dorostkar, Mario M., Khan, Deeba, Pollak, Daniela D., Kubista, Helmut, Boehm, Stefan, Koenig, Xaver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621994/
https://www.ncbi.nlm.nih.gov/pubmed/26211808
http://dx.doi.org/10.1111/bph.13262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621994/
https://www.ncbi.nlm.nih.gov/pubmed/26211808
http://dx.doi.org/10.1111/bph.13262

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