Cargando…

δ Subunit‐containing GABA(A) receptors are preferred targets for the centrally acting analgesic flupirtine

BACKGROUND AND PURPOSE: The K(v)7 channel activator flupirtine is a clinical analgesic characterized as ‘selective neuronal potassium channel opener’. Flupirtine was found to exert comparable actions at GABA(A) receptors and K(v)7 channels in neurons of pain pathways, but not in hippocampus. EXPERIM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klinger, Felicia, Bajric, Mirnes, Salzer, Isabella, Dorostkar, Mario M., Khan, Deeba, Pollak, Daniela D., Kubista, Helmut, Boehm, Stefan, Koenig, Xaver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621994/ https://www.ncbi.nlm.nih.gov/pubmed/26211808 http://dx.doi.org/10.1111/bph.13262

Ejemplares similares

Antiepileptic activity and subtype-selective action of flupirtine at GABA(A) receptors
por: Bajrić, Mirnes, et al.
Publicado: (2012)

The non-opioid analgesic flupirtine is a modulator of GABA(A )receptors involved in pain sensation
por: Popovici, Felicia, et al.
Publicado: (2008)

The anticonvulsant retigabine is a subtype selective modulator of GABA (A) receptors
por: Treven, Marco, et al.
Publicado: (2015)

Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy
por: Yadav, Ghanshyam, et al.
Publicado: (2015)

Flupirtine: Clinical pharmacology
por: Harish, S, et al.
Publicado: (2012)

Phosphorylation regulates the sensitivity of voltage‐gated Kv7.2 channels towards phosphatidylinositol‐4,5‐bisphosphate
por: Salzer, Isabella, et al.
Publicado: (2016)

Ca(2+) activated Cl(−) channels as targets for analgesics
por: Salzer, Isabella, et al.
Publicado: (2017)

Stoichiometry of δ subunit containing GABA(A) receptors
por: Patel, B, et al.
Publicado: (2014)

Correlation versus Causation? Pharmacovigilance of the Analgesic Flupirtine Exemplifies the Need for Refined Spontaneous ADR Reporting
por: Anderson, Nora, et al.
Publicado: (2011)

Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats
por: Patil, Madhoosudan A., et al.
Publicado: (2018)

Evidence for a Physiological Role of T-Type Ca Channels in Ventricular Cardiomyocytes of Adult Mice
por: Marksteiner, Jessica, et al.
Publicado: (2022)

Comparison of analgesic efficacy of flupirtine maleate and ibuprofen in gynaecological ambulatory surgeries: A randomized controlled trial
por: Ahuja, Vanita, et al.
Publicado: (2015)

δ-Subunit Containing GABA(A) Receptors Modulate Respiratory Networks
por: Montandon, Gaspard, et al.
Publicado: (2017)

Gabapentin increases expression of δ subunit-containing GABA(A) receptors
por: Yu, Jieying, et al.
Publicado: (2019)

Functional implications of K(V)7 channel phosphorylation
por: Salzer, Isabella, et al.
Publicado: (2012)

Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons
por: Ferando, Isabella, et al.
Publicado: (2013)

Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors
por: Jiménez-González, Cristina, et al.
Publicado: (2011)

Cerebellum-Specific Deletion of the GABA(A) Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior
por: Rudolph, Stephanie, et al.
Publicado: (2020)

Ovarian cycle-linked plasticity of δ-GABA(A) receptor subunits in hippocampal interneurons affects γ oscillations in vivo
por: Barth, Albert M. I., et al.
Publicado: (2014)

Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K(+) Currents in Motor Neuron-Like Cells
por: Wu, Sheng-Nan, et al.
Publicado: (2012)

Calcium current properties in dystrophin‐deficient ventricular cardiomyocytes from aged mdx mice
por: Rubi, Lena, et al.
Publicado: (2018)

Decreased inward rectifier potassium current I(K1) in dystrophin-deficient ventricular cardiomyocytes
por: Rubi, Lena, et al.
Publicado: (2016)

Psilocybin Therapy of Psychiatric Disorders Is Not Hampered by hERG Potassium Channel–Mediated Cardiotoxicity
por: Hackl, Benjamin, et al.
Publicado: (2021)

Identification of transthyretin as a novel interacting partner for the δ subunit of GABA(A) receptors
por: Zhou, Li, et al.
Publicado: (2019)

δ Subunit-containing GABA(A) receptor prevents overgeneralization of fear in adult mice
por: Zhang, Wen-Hua, et al.
Publicado: (2017)

Pharmacological and Biophysical Characteristics of Picrotoxin-Resistant, δSubunit-Containing GABA(A) Receptors
por: Shu, Hong-Jin, et al.
Publicado: (2021)

Inhibition of Spontaneous Contractility of Isolated Caprine Ureter by Flupirtine
por: Naik, Girish S, et al.
Publicado: (2018)

Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses
por: Makoukji, Joelle, et al.
Publicado: (2018)

Exogenous Flupirtine as Potential Treatment for CLN3 Disease
por: Maalouf, Katia, et al.
Publicado: (2020)

Flupirtine in the Management of Taxane-induced Pain in Cancer Patients
por: Paul, Anusha, et al.
Publicado: (2022)

Analgesic Action of Acetaminophen via Kv7 Channels
por: Stampf, Jan-Luca, et al.
Publicado: (2022)

Virally-induced expression of GABA(A) receptor δ subunits following their pathological loss reveals their role in regulating GABA(A) receptor assembly
por: Sun, Yu, et al.
Publicado: (2022)

Effect of flupirtine on the growth and viability of U373 malignant glioma cells
por: Panchanathan, Elango, et al.
Publicado: (2013)

Role of flupirtine in reducing preoperative anxiety of patients undergoing craniotomy procedure
por: Yadav, Ghanshyam, et al.
Publicado: (2017)

Efficacy of flupirtine for postoperative pain: A systematic review and meta-analysis
por: Dey, Samarjit, et al.
Publicado: (2023)

Oxytocin, GABA, and TRPV1, the Analgesic Triad?
por: Gonzalez-Hernandez, Abimael, et al.
Publicado: (2018)

The contribution of δ subunit-containing GABA(A) receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex
por: Ye, Zhiwen, et al.
Publicado: (2013)

Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABA(A) Receptor Inhibition Require the δ-Subunit
por: Littlejohn, Erica L., et al.
Publicado: (2021)

Mice Lacking GABA(A) Receptor δ Subunit Have Altered Pharmaco-EEG Responses to Multiple Drugs
por: Grotell, Milo, et al.
Publicado: (2021)

Hulk-Like Urine: A Case of Green Urine Caused by Flupirtine Intoxication
por: Vilela, Maria, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l90ptugfrit50fh7jsc9pgd8l4