Cargando…

High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation

Although antigen-binding fragments (Fabs) of antibodies constitute established tracers for in vivo radiodiagnostics, their functionality is hampered by a very short circulation half-life. PASylation, the genetic fusion with a long, conformationally disordered amino acid chain comprising Pro, Ala and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mendler, Claudia T, Friedrich, Lars, Laitinen, Iina, Schlapschy, Martin, Schwaiger, Markus, Wester, Hans-Jürgen, Skerra, Arne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622060/ https://www.ncbi.nlm.nih.gov/pubmed/25484039 http://dx.doi.org/10.4161/19420862.2014.985522

Ejemplares similares

First In-Human Medical Imaging with a PASylated (89)Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer
por: Richter, Antonia, et al.
Publicado: (2020)

Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo
por: Peplau, Emanuel, et al.
Publicado: (2021)

PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
por: Schlapschy, Martin, et al.
Publicado: (2013)

Improvement of Certolizumab Fab′ properties by PASylation technology
por: Mazaheri, Somayeh, et al.
Publicado: (2020)

PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology
por: Binder, Uli, et al.
Publicado: (2020)

Direct Affinity Purification of Long‐Acting PASylated Proteins with Therapeutic Potential Using L‐Prolinamide for Mild Elution
por: Schilz, Jonas, et al.
Publicado: (2022)

Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication
por: Nganou-Makamdop, Krystelle, et al.
Publicado: (2018)

Single chain Fab (scFab) fragment
por: Hust, Michael, et al.
Publicado: (2007)

Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology
por: Aghaabdollahian, Safieh, et al.
Publicado: (2019)

Production of single chain Fab (scFab) fragments in Bacillus megaterium
por: Jordan, Eva, et al.
Publicado: (2007)

Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM
por: Jeckelmann, Jean-Marc, et al.
Publicado: (2022)

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
por: Beckmann, Roland, et al.
Publicado: (2021)

Production of Antibody Fab Fragments in Escherichia coli
por: Tachibana, Hiroshi, et al.
Publicado: (2011)

PASylated Urate Oxidase Enzyme: Enhancing Biocatalytic Activity, Physicochemical Properties, and Plasma Half-Life
por: Najjari, Abbas, et al.
Publicado: (2022)

Bicistronic DNA display for in vitro selection of Fab fragments
por: Sumida, Takeshi, et al.
Publicado: (2009)

Comparison of cyclic RGD peptides for α(v)β(3) integrin detection in a rat model of myocardial infarction
por: Laitinen, Iina, et al.
Publicado: (2013)

Anti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study
por: Eddleston, Michael, et al.
Publicado: (2018)

Dosimetric evaluation and radioimmunotherapy of anti-tumour multivalent Fab́ fragments
por: Casey, J L, et al.
Publicado: (1999)

Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators
por: Kyrchanova, O. V., et al.
Publicado: (2022)

Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization
por: Mitropoulou, Alkistis N., et al.
Publicado: (2020)

HIV-2 neutralization by intact V3-specific Fab fragments
por: Sourial, Samer, et al.
Publicado: (2008)

Use of digoxin-specific antibody fragments (Fab) in the management of digoxin poisoning.
por: Brown, J. H., et al.
Publicado: (1986)

Modification of Fab Fragments by Dibromopyridazinediones Carrying Mono- and Double-Biotin Functionalities
por: Matsushita, Takahiko, et al.
Publicado: (2022)

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

Development and Characterization of Chimeric Anti‐carcinoembryonic Antigen Monoclonal Antibodies and Their Fab Fragments
por: Kamigaki, Takashi, et al.
Publicado: (1994)

QbD Based Media Development for the Production of Fab Fragments in E. coli
por: Kumar, Deepak, et al.
Publicado: (2019)

Enhanced Thermal Stability and Reduced Aggregation in an Antibody Fab Fragment at Elevated Concentrations
por: Zhang, Cheng, et al.
Publicado: (2023)

Production in Bacteria and Characterization of Engineered Humanized Fab Fragment against the Nodal Protein
por: Sivaccumar, Jwala P., et al.
Publicado: (2023)

Therapy and Imaging of Pancreatic Carcinoma Xenografts with Radioiodine‐labeled Chimeric Monoclonal Antibody A10 and Its Fab Fragment
por: Kamigaki, Takashi, et al.
Publicado: (1995)

In Vitro Selection of Fab Fragments by mRNA Display and Gene-Linking Emulsion PCR
por: Sumida, Takeshi, et al.
Publicado: (2012)

The Intrinsic Dynamics and Unfolding Process of an Antibody Fab Fragment Revealed by Elastic Network Model
por: Su, Ji-Guo, et al.
Publicado: (2015)

Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment
por: Kirley, Terence L, et al.
Publicado: (2015)

Synthetic antigen-binding fragments (Fabs) against S. mutans and S. sobrinus inhibit caries formation
por: Alam, Md. Kausar, et al.
Publicado: (2018)

Effect of DNA sequence of Fab fragment on yield characteristics and cell growth of E. coli
por: Kulmala, Antti, et al.
Publicado: (2017)

Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments
por: Dewulf, Jonatan, et al.
Publicado: (2022)

Improved fluorescent signal in expansion microscopy using fluorescent Fab fragment secondary antibodies
por: Sherry, David M., et al.
Publicado: (2022)

Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis
por: Gaudin, Alice, et al.
Publicado: (2015)

Matching the Decay Half-Life with the Biological Half-Life: ImmunoPET Imaging with (44)Sc-Labeled Cetuximab Fab Fragment
por: Chakravarty, Rubel, et al.
Publicado: (2014)

Strategies for the production of isotopically labelled Fab fragments of therapeutic antibodies in Komagataella phaffii (Pichia pastoris) and Escherichia coli for NMR studies
por: Gagné, Donald, et al.
Publicado: (2023)

Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin.
por: Otsuji, E., et al.
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_529h4e0o8ml6292pa7n45npdm3