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Genome-wide association study of 29 morphological traits in Aegilops tauschii
Aegilops tauschii is the D-genome progenitor of hexaploid wheat (Triticum aestivum). It is considered to be an important source of genetic variation for wheat breeding, and its genome is an invaluable reference for wheat genomics. We conducted a genome-wide association study using 7,185 single nucle...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622089/ https://www.ncbi.nlm.nih.gov/pubmed/26503608 http://dx.doi.org/10.1038/srep15562 |
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author | Liu, Yaxi Wang, Lang Mao, Shuangshuang Liu, Kun Lu, Yanli Wang, Jirui Wei, Yuming Zheng, Youliang |
author_facet | Liu, Yaxi Wang, Lang Mao, Shuangshuang Liu, Kun Lu, Yanli Wang, Jirui Wei, Yuming Zheng, Youliang |
author_sort | Liu, Yaxi |
collection | PubMed |
description | Aegilops tauschii is the D-genome progenitor of hexaploid wheat (Triticum aestivum). It is considered to be an important source of genetic variation for wheat breeding, and its genome is an invaluable reference for wheat genomics. We conducted a genome-wide association study using 7,185 single nucleotide polymorphism (SNP) markers across 322 diverse accessions of Ae. tauschii that were systematically phenotyped for 29 morphological traits in order to identify marker-trait associations and candidate genes, assess genetic diversity, and classify the accessions based on phenotypic data and genotypic comparison. Using the general linear model and mixed linear model, we identified a total of 18 SNPs significantly associated with 10 morphological traits. Systematic search of the flanking sequences of trait-associated SNPs in public databases identified several genes that may be linked to variations in phenotypes. Cluster analysis using phenotypic data grouped accessions into four clusters, while accessions in the same cluster were not from the same Ae. tauschii subspecies or from the same area of origin. This work establishes a fundamental research platform for association studies in Ae. tauschii and also provides useful information for understanding the genetic mechanism of agronomic traits in wheat. |
format | Online Article Text |
id | pubmed-4622089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46220892015-10-29 Genome-wide association study of 29 morphological traits in Aegilops tauschii Liu, Yaxi Wang, Lang Mao, Shuangshuang Liu, Kun Lu, Yanli Wang, Jirui Wei, Yuming Zheng, Youliang Sci Rep Article Aegilops tauschii is the D-genome progenitor of hexaploid wheat (Triticum aestivum). It is considered to be an important source of genetic variation for wheat breeding, and its genome is an invaluable reference for wheat genomics. We conducted a genome-wide association study using 7,185 single nucleotide polymorphism (SNP) markers across 322 diverse accessions of Ae. tauschii that were systematically phenotyped for 29 morphological traits in order to identify marker-trait associations and candidate genes, assess genetic diversity, and classify the accessions based on phenotypic data and genotypic comparison. Using the general linear model and mixed linear model, we identified a total of 18 SNPs significantly associated with 10 morphological traits. Systematic search of the flanking sequences of trait-associated SNPs in public databases identified several genes that may be linked to variations in phenotypes. Cluster analysis using phenotypic data grouped accessions into four clusters, while accessions in the same cluster were not from the same Ae. tauschii subspecies or from the same area of origin. This work establishes a fundamental research platform for association studies in Ae. tauschii and also provides useful information for understanding the genetic mechanism of agronomic traits in wheat. Nature Publishing Group 2015-10-27 /pmc/articles/PMC4622089/ /pubmed/26503608 http://dx.doi.org/10.1038/srep15562 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Yaxi Wang, Lang Mao, Shuangshuang Liu, Kun Lu, Yanli Wang, Jirui Wei, Yuming Zheng, Youliang Genome-wide association study of 29 morphological traits in Aegilops tauschii |
title | Genome-wide association study of 29 morphological traits in Aegilops tauschii |
title_full | Genome-wide association study of 29 morphological traits in Aegilops tauschii |
title_fullStr | Genome-wide association study of 29 morphological traits in Aegilops tauschii |
title_full_unstemmed | Genome-wide association study of 29 morphological traits in Aegilops tauschii |
title_short | Genome-wide association study of 29 morphological traits in Aegilops tauschii |
title_sort | genome-wide association study of 29 morphological traits in aegilops tauschii |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622089/ https://www.ncbi.nlm.nih.gov/pubmed/26503608 http://dx.doi.org/10.1038/srep15562 |
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