Combined olaparib and oxaliplatin inhibits tumor proliferation and induces G(2)/M arrest and γ-H2AX foci formation in colorectal cancer

BACKGROUND: Poly (ADP-ribose) polymerase 1 (PARP1) has an important role in homologous recombination repair. The purpose of this study was to investigate the effect of PARP1 inhibitor on oxaliplatin treatment for colorectal cancer (CRC). METHODS: A cell counting kit-8 assay was used to determine the...

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Detalles Bibliográficos
Autores principales: Xu, Kaiwu, Chen, Zhihui, Cui, Yi, Qin, Changjiang, He, Yulong, Song, Xinming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622093/
https://www.ncbi.nlm.nih.gov/pubmed/26543375
http://dx.doi.org/10.2147/OTT.S89154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622093/
https://www.ncbi.nlm.nih.gov/pubmed/26543375
http://dx.doi.org/10.2147/OTT.S89154

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