Antibacterial activity and therapeutic efficacy of Fl-P(R)P(R)P(L)-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection

The antibacterial activities and therapeutic efficacy of the cationic, unnatural proline-rich peptide Fl-P(R)P(R)P(L)-5 were evaluated against multidrug-resistant Staphylococcus aureus in a mouse model of skin infection. Fl-P(R)P(R)P(L)-5 showed potent activity against all clinical isolates of S. au...

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Detalles Bibliográficos
Autores principales: Thangamani, Shankar, Nepal, Manish, Chmielewski, Jean, Seleem, Mohamed N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622452/
https://www.ncbi.nlm.nih.gov/pubmed/26543355
http://dx.doi.org/10.2147/DDDT.S94505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622452/
https://www.ncbi.nlm.nih.gov/pubmed/26543355
http://dx.doi.org/10.2147/DDDT.S94505

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