Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody

Herein, we describe the generation and characterization of BI 655066, a novel, highly potent neutralizing anti-interleukin-23 (IL23) monoclonal antibody in clinical development for autoimmune conditions, including psoriasis and Crohn's disease. IL23 is a key driver of the differentiation, maint...

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Detalles Bibliográficos
Autores principales: Singh, Sanjaya, Kroe-Barrett, Rachel R, Canada, Keith A, Zhu, Xiang, Sepulveda, Eliud, Wu, Helen, He, Yaqin, Raymond, Ernest L, Ahlberg, Jennifer, Frego, Lee E, Amodeo, Laura M, Catron, Katrina M, Presky, David H, Hanke, Jeffrey H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622456/
https://www.ncbi.nlm.nih.gov/pubmed/25905918
http://dx.doi.org/10.1080/19420862.2015.1032491

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