Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype

The CpG Island Methylator Phenotype (CIMP) is fundamental to an important subset of colorectal cancer; however, its cause is unknown. CIMP is associated with microsatellite instability but is also found in BRAF mutant microsatellite stable cancers that are associated with poor prognosis. The isocitr...

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Detalles Bibliográficos
Autores principales: Whitehall, VLJ, Dumenil, TD, McKeone, DM, Bond, CE, Bettington, ML, Buttenshaw, RL, Bowdler, L, Montgomery, GW, Wockner, LF, Leggett, BA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622530/
https://www.ncbi.nlm.nih.gov/pubmed/25496513
http://dx.doi.org/10.4161/15592294.2014.971624

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