An affibody-adalimumab hybrid blocks combined IL-6 and TNF-triggered serum amyloid A secretion in vivo

In inflammatory disease conditions, the regulation of the cytokine system is impaired, leading to tissue damages. Here, we used protein engineering to develop biologicals suitable for blocking a combination of inflammation driving cytokines by a single construct. From a set of interleukin (IL)-6-bin...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Feifan, Gudmundsdotter, Lindvi, Akal, Anastassja, Gunneriusson, Elin, Frejd, Fredrik, Nygren, Per-Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622551/
https://www.ncbi.nlm.nih.gov/pubmed/25484067
http://dx.doi.org/10.4161/mabs.36089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622551/
https://www.ncbi.nlm.nih.gov/pubmed/25484067
http://dx.doi.org/10.4161/mabs.36089

Ejemplares similares