Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β

Interleukin-1 (IL-1) cytokines such as IL-1α, IL-1β, and IL-1Ra contribute to immune regulation and inflammatory processes by exerting a wide range of cellular responses, including expression of cytokines and chemokines, matrix metalloproteinases, and nitric oxide synthetase. IL-1α and IL-1β bind to...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacy, Susan E, Wu, Chengbin, Ambrosi, Dominic J, Hsieh, Chung-Ming, Bose, Sahana, Miller, Renee, Conlon, Donna M, Tarcsa, Edit, Chari, Ravi, Ghayur, Tariq, Kamath, Rajesh V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622731/
https://www.ncbi.nlm.nih.gov/pubmed/25764208
http://dx.doi.org/10.1080/19420862.2015.1026501

Ejemplares similares

Ejemplares similares