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Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma

Pathologic c-Myc expression is frequently detected in human cancers, including Merkel cell carcinoma (MCC), an aggressive skin cancer with no cure for metastatic disease. Bromodomain protein 4 (BRD4) regulates gene transcription by binding to acetylated histone H3 lysine 27 (H3K27Ac) on the chromati...

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Detalles Bibliográficos
Autores principales:	Sengupta, Deepanwita, Kannan, Aarthi, Kern, Malan, Moreno, Mauricio A, Vural, Emre, Stack, Brendan, Suen, James Y, Tackett, Alan J, Gao, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622756/ https://www.ncbi.nlm.nih.gov/pubmed/25941994 http://dx.doi.org/10.1080/15592294.2015.1034416

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