Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist

The CD28 superagonist (CD28SA) TGN1412 was administered to humans as an agent that can selectively activate and expand regulatory T cells but resulted in uncontrolled T cell activation accompanied by cytokine storm. The molecular mechanisms that underlie this uncontrolled T cell activation are uncle...

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Detalles Bibliográficos
Autores principales: Thaventhiran, Thilipan, Alhumeed, Naif, Yeang, Han XA, Sethu, Swaminathan, Downey, Jocelyn S, Alghanem, Ahmad F, Olayanju, Adedamola, Smith, Emma L, Cross, Michael J, Webb, Steven D, Williams, Dominic P, Bristow, Adrian, Ball, Christina, Stebbings, Richard, Sathish, Jean G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622985/
https://www.ncbi.nlm.nih.gov/pubmed/25517314
http://dx.doi.org/10.4161/mabs.29758

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