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Cross-reactive and pre-existing antibodies to therapeutic antibodies—Effects on treatment and immunogenicity
The potential for immunogenicity is an ever-present concern during the development of biopharmaceuticals. Therapeutic antibodies occasionally elicit an antibody response in patients, which can result in loss of response or adverse effects. However, antibodies that bind a drug are sometimes found in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623040/ https://www.ncbi.nlm.nih.gov/pubmed/25962087 http://dx.doi.org/10.1080/19420862.2015.1048411 |