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Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction
Cardiac cell therapy is a strategy to treat patients with chronic myocardial infarction (MI). No consensus exists regarding the optimal cell type. First, a comparison between autologous bone marrow-derived mononuclear cells (BMMNC) and mesenchymal stem cells (MSC) on therapeutic efficacy after MI wa...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623074/ https://www.ncbi.nlm.nih.gov/pubmed/26382088 http://dx.doi.org/10.1007/s12265-015-9643-3 |
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| author | van der Spoel, T. I. G. Gathier, W. A. Koudstaal, S. van Slochteren, F. of Lorkeers, S. Jansen Sluijter, J. P. G. Hoefer, I. E. Steendijk, P. Cramer, M. J. M. Doevendans, P. A. van Belle, E. Chamuleau, S. A. J. |
| author_facet | van der Spoel, T. I. G. Gathier, W. A. Koudstaal, S. van Slochteren, F. of Lorkeers, S. Jansen Sluijter, J. P. G. Hoefer, I. E. Steendijk, P. Cramer, M. J. M. Doevendans, P. A. van Belle, E. Chamuleau, S. A. J. |
| author_sort | van der Spoel, T. I. G. |
| collection | PubMed |
| description | Cardiac cell therapy is a strategy to treat patients with chronic myocardial infarction (MI). No consensus exists regarding the optimal cell type. First, a comparison between autologous bone marrow-derived mononuclear cells (BMMNC) and mesenchymal stem cells (MSC) on therapeutic efficacy after MI was performed. Next, the effect of repetitive, NOGA-guided transendocardial injection was determined via a crossover design. Nineteen pigs were allocated in three groups: (1) placebo (at 4 and 8 weeks), (2) MSC (followed by placebo at 8 weeks), or (3) BMMNC (followed by MSC at 8 weeks) delivery including a priming strategy to enhance MSC effect. At 4 weeks, ejection fraction (EF) was significantly improved after MSC injection and not by BMMNC injection. After 8 weeks, no difference was observed in EF between cell-treated groups demonstrating the positive systolic effect of MSC. This study showed that MSC rather than BMMNC injection improves systolic function in chronic MI. |
| format | Online Article Text |
| id | pubmed-4623074 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Springer US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46230742015-10-30 Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction van der Spoel, T. I. G. Gathier, W. A. Koudstaal, S. van Slochteren, F. of Lorkeers, S. Jansen Sluijter, J. P. G. Hoefer, I. E. Steendijk, P. Cramer, M. J. M. Doevendans, P. A. van Belle, E. Chamuleau, S. A. J. J Cardiovasc Transl Res Article Cardiac cell therapy is a strategy to treat patients with chronic myocardial infarction (MI). No consensus exists regarding the optimal cell type. First, a comparison between autologous bone marrow-derived mononuclear cells (BMMNC) and mesenchymal stem cells (MSC) on therapeutic efficacy after MI was performed. Next, the effect of repetitive, NOGA-guided transendocardial injection was determined via a crossover design. Nineteen pigs were allocated in three groups: (1) placebo (at 4 and 8 weeks), (2) MSC (followed by placebo at 8 weeks), or (3) BMMNC (followed by MSC at 8 weeks) delivery including a priming strategy to enhance MSC effect. At 4 weeks, ejection fraction (EF) was significantly improved after MSC injection and not by BMMNC injection. After 8 weeks, no difference was observed in EF between cell-treated groups demonstrating the positive systolic effect of MSC. This study showed that MSC rather than BMMNC injection improves systolic function in chronic MI. Springer US 2015-09-17 2015 /pmc/articles/PMC4623074/ /pubmed/26382088 http://dx.doi.org/10.1007/s12265-015-9643-3 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| spellingShingle | Article van der Spoel, T. I. G. Gathier, W. A. Koudstaal, S. van Slochteren, F. of Lorkeers, S. Jansen Sluijter, J. P. G. Hoefer, I. E. Steendijk, P. Cramer, M. J. M. Doevendans, P. A. van Belle, E. Chamuleau, S. A. J. Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction |
| title | Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction |
| title_full | Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction |
| title_fullStr | Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction |
| title_full_unstemmed | Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction |
| title_short | Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction |
| title_sort | autologous mesenchymal stem cells show more benefit on systolic function compared to bone marrow mononuclear cells in a porcine model of chronic myocardial infarction |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623074/ https://www.ncbi.nlm.nih.gov/pubmed/26382088 http://dx.doi.org/10.1007/s12265-015-9643-3 |
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