Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs

Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) are new tools for producing gene knockout (KO) animals. The current study reports produced genetically modified pigs, in which two endogenous genes were knocked out. Porcine fibroblast cell lines were derived f...

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Detalles Bibliográficos
Autores principales: MIYAGAWA, Shuji, MATSUNARI, Hitomi, WATANABE, Masahito, NAKANO, Kazuaki, UMEYAMA, Kazuhiro, SAKAI, Rieko, TAKAYANAGI, Shuko, TAKEISHI, Toki, FUKUDA, Tooru, YASHIMA, Sayaka, MAEDA, Akira, EGUCHI, Hiroshi, OKUYAMA, Hiroomi, NAGAYA, Masaki, NAGASHIMA, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623151/
https://www.ncbi.nlm.nih.gov/pubmed/26227017
http://dx.doi.org/10.1262/jrd.2015-058

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