The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent

The colorectal cancer is the leading contributor of cancer-related mortality. Mammalian target of rapamycin (mTOR), existing in 2 complexes (mTORC1/2), is frequently dysregulated and constitutively activated in colorectal cancers. It represents an important drug target. Here we found that INK-128, t...

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Detalles Bibliográficos
Autores principales: Li, Chen, Cui, Jian-Feng, Chen, Min-Bin, Liu, Chao-Ying, Liu, Feng, Zhang, Qian-De, Zou, Jian, Lu, Pei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623257/
https://www.ncbi.nlm.nih.gov/pubmed/25692620
http://dx.doi.org/10.4161/15384047.2014.972274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623257/
https://www.ncbi.nlm.nih.gov/pubmed/25692620
http://dx.doi.org/10.4161/15384047.2014.972274

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