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Genome-wide analysis of chemically induced mutations in mouse in phenotype-driven screens

BACKGROUND: N-ethyl-N-nitrosourea (ENU) mutagen has become the method of choice for inducing random mutations for forward genetics applications. However, distinguishing induced mutations from sequencing errors or sporadic mutations is difficult, which has hampered surveys of potential biases in the...

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Detalles Bibliográficos
Autores principales:	Bauer, Denis C., McMorran, Brendan J., Foote, Simon J., Burgio, Gaetan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623266/ https://www.ncbi.nlm.nih.gov/pubmed/26503232 http://dx.doi.org/10.1186/s12864-015-2073-4

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